PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements of pyroptosis, apoptosis, and necroptosis. PANoptosis is governed by a newly discovered cytoplasmic multimeric protein complex known as
Pyroptosis, an inflammatory form of PCD, has emerged as a promising avenue for antitumor treatments. Pyroptosis was first described in 1986. Friedlander et al. treated primary mouse macrophages with the anthrax toxin and found that the macrophages rapidly underwent cytolytic death with a non-specific...
However, excess copper can disrupt cellular homeostasis, leading to the induction of cuproptosis. This form of cell death is characterized by the aggregation of lipoylated proteins in the tricarboxylic acid (TCA) cycle, resulting in proteotoxic stress and ultimately triggering mitochondrial dysfunction ...
Five percent of PCa cases are found to have metastasized at the time of initial diagnosis, with a five-year survival rate of less than 30% [3]. Therefore, new approaches need to be explored for managing or curing PCa. Disulfidptosis is a novel form of cell death distinct from ...
In this context, exploring the molecular mechanisms that regulate PCD provides new ideas for the treatment of PDAC. Disulfidptosis represents a specific form of metabolism-related PCD, occurring when intracellular cystine levels become overloaded under glucose starvation conditions [13, 14]. When ...
Mitochondrial fusion refers to the process in which two mitochondria merge to form a single mitochondrion [55]. This process is not limited to the relative positions of the two mitochondria and can occur at either the ends or the sides. Due to the double-membrane structure of mitochondria, ...
Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease states. This condition can lead to significant he
Pyroptosis is a new form of PCD that is thought to be involved in the body’s defense against pathogens. In contrast to immunosuppressed apoptosis, pyroptosis is characterized by cell expansion until membrane rupture, which results in the release of cytokines and the activation of a cascade of ...
Pyroptosis is a notably inflammatory form of lytic PCD which has a key role in innate immunity and tumor development [34,43,44]. The term “pyroptosis” was initially proposed by Cookson and Brennan in 2001 to characterize this distinct process [45]. Originating from Greek roots, “pyroptosis...
With the intensification of the greenhouse effect, a series of natural phenomena, such as global warming, are gradually recognized; when the ambient temperature increases to the extent that it causes heat stress in plants, agricultural production will in