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Realizing the immense clinical potential of mRNA-based drugs will require continued development of methods to safely deliver the bioactive agents with high efficiency and without triggering side effects. In this regard, lipid nanoparticles have been successfully utilized to improve mRNA delivery and protec...
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LNPs containing a high amount of ICL (more than 40 mol%), DSPC, and cholesterol can form inverted micelles around RNA therapeutics. Conversely, those with a lower amount of ICL (20 mol%) and a higher DSPC content (30 mol%) result in solid cores primarily composed of inverted micelles,...
Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int. 1998;15(6):655–66. Article CAS PubMed Google Scholar Li Volti G, Musumeci T, Pignatello R, Murabito P, Barbagallo I, Carbone C, et al. Antioxidant potential of different ...
After performing double centering onD, one can apply SVD toB. SinceBis symmetric, the decomposition is of the formB=UVUT. Hence,B=X−1NX11T=UV12, where the columns ofBare the coordinates of data, with the mean of the data being moved to the original point. ...
Molecular evolution is usually described assuming a neutral or weakly non-neutral substitution model. Recently, new data have become available on evolution of sequence regions under a selective pressure, e.g. transcription factor binding sites. To recons
To achieve zero voltage switching on switch node of QBd, the turn-on (tABSET) delays of FETs QA and QB must be initially set based on the interaction of LS and the theoretical switch node capacitance. The following equations are used to set tABSET initially. Equate shim inductance to two...
In order to achieve zero voltage switching on switch node of QBd, the turn-on (tABSET) delays of FETs QA and QB needs to be initially set based on the interaction of LS and the theoretical switch node capacitance. The following equations are used to set tABSET initially. Equate shim ...