Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) can be used to treat heart diseases; however, the optimal maturity of hiPSC-CMs for effective regenerative medicine remains unclear. We aimed to investigate the benefits of long-
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Plasma and cerebrospinal fluid levels of neurofilament light (NfL), a marker of axonal degeneration, have previously been reported to be raised in patients with clinically diagnosed Alzheimer’s disease (AD). Activated microglia, an intrinsic inflammator
Green fluorescent protein (GFP) has been found in a wide range of Cnidaria, a basal group of metazoans in which it is associated with pigmentation, fluorescence, and light absorbance. A GFP has been recently discovered in the pigmentless chordate Branchi
Previously we described a transdominant negative mutant of the HIV-1 Tat protein, termed Nullbasic, that downregulated the steady state levels of unspliced and singly spliced viral mRNA, an activity caused by inhibition of HIV-1 Rev activity. Nullbasic a
Chordate evolution is a history of innovations that is marked by physical and behavioral specializations, which led to the development of a variety of forms from a single ancestral group. Among other important characteristics, vertebrates obtained a well
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who received osimertinib than in controls in terms of efficacy measures [87]. In other studies, ALK inhibitors improved PSF compared with chemotherapy, and alectinib and brigatinib improved PFS compared with crizotinib and ceritinib [80]. In addition, alectinib improved OS compared with chemotherapy...
[134,135]. In their natural environment, the components of elastin first converge in the form of a water-soluble precursor molecule called their tropoelastin, and then these precursors combine to form elastin fibers by forming covalent cross-links (Fig.12). Genetic engineering techniques and the ...
Claudins (CLDNs) are a family of proteins and are important components of tight junctions (TJs) [1], which form a paracellular barrier to control the flow of molecules between cells. CLDNs have transmembrane domains and an N-terminus and a C-terminus in the cytoplasm (Fig. 1). Different...