crassa and egtD, egtE genes form M. smegmatis with multiple rounds of mutations [25]. As for another representative model microorganism, Saccharomyces cerevisiae, it was also used to produce EGT. In 2019, Van der Hoek et al. described the engineering of S. cerevisiae to produce 598 mg/L ...
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Subtilisin-like proteases (SLPs) form a superfamily of enzymes that act to degrade protein substrates. In fungi, SLPs can play either a general nutritive role, or may play specific roles in cell metabolism, or as pathogenicity or virulence factors. Fifte
larger deletions or duplications (copy number variants, CNVs) have been shown to play a role in the etiology of ASDs [15–27]. Despite the observed inheritance of many ASD predisposition CNVs from an unaffected parent, the lack of extended, multi-generation pedigrees ...