Methylation plays multiple critical roles, such as diversifying natural products, increasing bioavailability and stability of small molecules, altering the potency and cytotoxicity of natural products, and regulating biological processes, such as epigenetics and initiation of metamorphosis in insects (Shinoda ...
Systemic thrombolysis, catheter-directed thrombolysis (CDT), and percutaneous pharmacomechanical thrombolysis (PPMT) using tissue plasminogen activator (tPA) have been reported. Tenecteplase (TNK) is a genetically engineered form of tPA with slower plasma clearance, greater resistance to plasminogen ...