(phaA3/phaB2/phaC1) strain showed about 1.7- to 3.9-fold higher volumetric PHB production (without ammonium sulfate; 1.88 ± 0.08 g l−1 and with 100 mM ammonium sulfate; 0.99 ± 0.05 g l−1) than those of the parent HJ (pLP-1.2) strain grown under nitrogen limited ...
Ferroptosis was involved in the imbalance of intestinal microenvironment homeostasis in Crohn’s Disease Crohn’s disease (CD), a common form of inflammatory bowel disease (IBD), is characterized by irreversible aberrant immune responses [59]. Public scRNA-seq dataset of the terminal ileum of patien...
Alzheimer's disease (AD)2 is a progressive and irreversible neurodegenerative disease that is the most common form of dementia in the elderly (1). Genetically, AD can be subdivided into two subgroups: early onset, familial Alzheimer's disease (FAD) and late onset, sporadic Alzheimer's disease...
Tumor immunotherapy has transformed neoplastic disease management, yet low response rates and immune complications persist as major challenges. Extracellular vesicles including exosomes have emerged as therapeutic agents actively involved in a diverse range of pathological conditions. Mounting evidence suggests t...
The mitochondria are essential organelles not only providing cellular energy in the form of ATP, but also regulating the inflammatory response and the cell death program. Mitochondrial dysfunction has been associated with various human diseases, including metabolic syndromes as well as inflammatory and ne...
2A). Further, the production of GABA by Lbr-6108 increased upon addition of 10,000 μg/mL (1.0%) free glutamate substrate in the form of MSG in the media (Fig. 2A). A 2.5-fold increase in GABA production was observed at T15 compared to its growth without added glutamate, followed ...
(Thermo Fisher, 20,164), following the manufacturer's instructions. The biotin-labeled RNA was initially immobilized on streptavidin magnetic beads and subsequently incubated with the specified protein extracts to form an RNA-binding protein complex. The resulting mixture containing the RNA-binding ...
First, the hippocampal damage and epileptic seizure in human TLE-HS patients form a mutually reinforcing process with a complex and still unclear pathogenesis [40]. The KA-induced epilepsy model represents acute hippocampal excitotoxic injury, was employed in this study to investigate the mechanisms ...
IER3 could accurately predict the outcomes of gliomasIgnoring the non-linear form of continuous data and directly introducing classification for model prediction is prone to losing much information. Here, we introduced the RCS method to detect the optimal cutoff of IER3 ...
Duplications resulting from an unbalanced form of X-Y [t(X;Y)] or X-autosome translocations [t(X;A)] are more rarely reported, with imbalance limited to the distal portion of Xq. About six cases of t(X;Y) have been reported in severely retarded males with non-fluorescent Y chromosome...