ALDH4A1 mutation leads to accumulation of P5C in mitochondria. P5C reacts with PLP to form PLP-P5C condensate, which reduces the concentration of PLP in the brain. Elevated P5C can be converted to proline, leading to mitochondrial stress Full size image The most common clinical manifestations...
First, the hippocampal damage and epileptic seizure in human TLE-HS patients form a mutually reinforcing process with a complex and still unclear pathogenesis [40]. The KA-induced epilepsy model represents acute hippocampal excitotoxic injury, was employed in this study to investigate the mechanisms ...
The low molecular weight thiol PTTH is the stable homodimeric form of pantetheine (Fig. S2a) and was previously shown to increase CoA levels both in vitro and in vivo [10, 43, 60]. We first confirmed that treatment with PTTH rapidly increased total CoA levels in encephalitogenic T ...
The mitochondria are essential organelles not only providing cellular energy in the form of ATP, but also regulating the inflammatory response and the cell death program. Mitochondrial dysfunction has been associated with various human diseases, including metabolic syndromes as well as inflammatory and ne...
The released products are subsequently further modified by additional enzymes, which are encoded by genes located near the NRPS and thus form the final product [18, 19]. Fusahexin Fusahexin (1), originally derived from strain F. graminearum PH-1, represents a cyclic hexapeptide consisting of ...
To form three sets of inputs, based on HVGs and stitched and unstitched SVGs, runPCA() from scater v1.32.1 [19] was run, subset to each gene set. Next, batch correction for capture area was performed with RunHarmony() from harmony v1.2.0 [21] using the computed principal ...
Protein drugs are of great importance in maintaining the normal functioning of living organisms. Indeed, they have been instrumental in combating tumors and genetic diseases for decades. Among these pharmaceutical agents, those that target intracellular
Of 1497 references identified from websites, 406 were not retrieved. Our inability to retrieve reports from 406 studies indicates that these studies were either inaccessible, untraceable, or unavailable in a form suitable for inclusion in the review. We have clarified this point in our methods ...
Furthermore, researchers identified three major isoforms of TMEM106B fibrils. The three isoforms differ in their structure of the middle region (A167 – M210), in which type I forms a loose amphipathic cavity, and type II and type III form increasingly tighter structures. In addition, the ...
The expert knowledge was formalized by the medical data scientist in the form of pre-defined list of elements modules using an entity-relationship model. An entity-relationship model defines an interrelated set of elements and the relationship that can exist among them [42]. 3. Implementation: ...