Across the globe, over 200 million annual malaria infections result in up to 660,000 deaths, 77% of which occur in children under the age of five years. Although prevention is important, malaria deaths are typically prevented by using antimalarial drugs
The production of veritable in-vitro models of bone tissue is essential to understand the biology of bone and its surrounding environment, to analyze the pathogenesis of bone diseases (e.g., osteoporosis, osteoarthritis, osteomyelitis, etc.), to develop effective therapeutic drug screening, and to ...
An increasing number of postmenopausal women are diagnosed with breast cancer at an older age (≥ 70 years). There is a lack of synthesised health utility data to support decision-making for managing breast cancer in this older population. This s
mongolicus and high nitrogen fixation efficiency, which can promote the growth of A. mongolicus, and has been applied in field production [21, 22]. Meanwhile, efficient non-symbiotic nitrogen fixing bacteria also need to be screened, and then combined with symbiotic rhizobia to form a multi-...
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Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon cancer has been widely investigated, studies on rectal cancer are very limited. Here, we performed multi-region whole-exome sequencing and single-cell
of the melanin biosynthesis pathway. For example, DevR and RlmA ofA. fumigatuscan recognize the DNA motifs ofpksPpromoter region and regulate it by acting as repressors and activators [28]. InPestalotiopsis fici, PfmaF stimulates PfmaH to positively regulate the expression of scytalone ...
TFBSs are traditionally modeled with position weight matrices (PWMs) [22]. Several databases such as JASPAR [23], HOCOMOCO [24], CisBP [25] and Transfac [26], propose position frequency matrices (PFM, which can be transformed in PWMs) for hundred of TFs. These PWMs can be used to ...
Schematic of immune response to the vaccine. Antigens are delivered to and bind with naïve dendritic cells to form mature antigen-presenting cells. Then the processed antigens bind with T-cell receptors on naïve CD4+cells or naïve CD8+cells, respectively. The stimulated T cells secrete ...
(PFMs) based on those alignments are supplied in Fig.S4. These PFMs are also represented by sequence logos that will be presented in the following sections, and the number of proteins within each TF family that successfully yielded a PFM are summarized in Fig.1. Thirteen of the motifs ...