Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life (QoL) of affected individuals as well as their families. Although the pathogenesis of the disorder is not yet completely understood, it appears to
Class V mutations lead to a reduced amount of functional CFTR protein [13,14,15,16,17] and class VI mutation cause an enhanced protein turnover. Patients carrying Class I–III mutations manifest a more severe form of disease. However, possible influences of gene modifiers for example TGF-...
Successful development of agents that improve cognition and behavior in Alzheimer’s disease (AD) is critical to improving the lives of patients manifesting the symptoms of this progressive disorder. There have been no recent approvals of cognitive enhan
32]. MlaA is an OM α-helical membrane protein. MlaA was predicted to be a periplasmic exposed lipoprotein involved in the removal of GPLs from the outer leaflet of the OM that interacted with nonspecific diffusion channels called porins (substrate < 600 Da, e.g., OmpF and ...
3′-Untranslated regions (3′UTRs) play crucial roles in mRNA metabolism, such as by controlling mRNA stability, translation efficiency, and localization. Intriguingly, in some genes the 3′UTR is longer than their coding regions, pointing to additional,
Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein dysfunction that manifests clinically as RYR1-related congenital myopathies (RY
Psoriasis (PsO) is a chronic, inflammatory skin disease with multiple systemic manifestations that can have a considerable negative impact on patients’ well-being [1-5]. Plaque psoriasis is the most common form of PsO, accounting for around 90% of cases [3,6]. It is characterized by erythe...
CREB, cAMP response element-binding protein; ERK1/2, extracellular regulated kinases 1 and 2; hCG, human chorionic gonadotrophin; LH, luteinising hormone; LH/CGR, luteinising hormone/choriogonadotrophin receptor; PDE, phosphodiesterase enzyme; Pl3K, phosphoinositide 3-kinases; PKA, protein kinase A...
Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these