It shouldn’t remove information of cellular identity to form “average cells” or collapse different cell types or states into one. Second, the network should be robust to the presence of different cell types in hq and lq data or an imbalance in their relative ratios. It should not, for ...
IL-12p70, the biologically active form of IL-12, is composed of two subunits: the constitutively expressed IL-12p35 and the inducible IL-12p40. IL-12p70 is one of the first pro-inflammatory cytokines released after antigens from the foreign agents [21]. Previous studies have demonstrated th...
We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While IL17RB has been linked to inflammation and malignancies in several organ systems, its function in the endometrium has not been inve
VSL2 and VL3-BA algorithms was used (http://www.pondr.com), the calculation and presentation of various sequence parameters associated with disordered protein sequences were provided with CIDER (Classification of Intrinsically Disordered Ensemble Regions (http://pappulab.wustl.edu/CIDER/analysis/)....
As another control, we show that RAD52, which forms large multimers and performs a related form of ssDNA end-joining involving microhomology, promotes similar Cy3-ssDNA complexes (Supplementary Fig. 7D). The data in Fig. 6h, i demonstrate that polymerase-helicase tethering facilitates ssDNA ...
BP1 undergoes liquid–liquid phase separation in vitro.ANet charge per residue (NCPR) of BP1 was calculated using the Classification of Intrinsically Disordered Ensemble Regions (CIDER) web server (http://pappulab.wustl.edu/CIDER/analysis/).BHydrophilicity plot of BP1 was predicted using ProtScale ...
LogP describes the differential solubility of a neutral compound with a single form in n-octanol and water. However, 95% of drugs have ionizable groups containing ionization and unionization forms. Thus, logD, which is pH dependent and measures the lipophilicity of an ionizable compound in a ...
Additionally, Cremer et al. uncovered a unique mechanism based on the accumulation of Gnd+and the counteranion into the collapsed form of the macromolecule at low concentrations of GndSCN. Gnd+pairs with the hydrated anion in solution, which in turn stabilizes the collapsed state of ELP. At low...
Plant expression of HBV antigens other than the standard S HBsAg has been attempted in recent years by a number of groups. The Arizona Biodesign Institute group, who pioneered much of the biofarming of HBV vaccines, showed in 2004 that the S form of HBsAg could be used via transient agroin...
used the smiles data of molecules in the form of strings as the model input and predicted various molecular properties, such as the melting and boiling points. when molecules are represented in nonstring forms, the relative positional information between atoms must be used as one of the inputs...