MRP2 is located in the luminal membrane of small intestinal cells and is responsible for re-secreting bile acids into the intestine lumen. Once in the portal vein, hepatocytes reabsorb the bile acids through the Na+-dependent taurocholic cotransporting polypeptide (NTCP) and organic anion transport...
HBV-related deaths rank tenth highest cause of death globally, with about 820,000 deaths worldwide reported each year [5, 6]. Sodium taurocholate cotransporting polypeptide (NTCP) is a key host receptor for the HBV to get into the cell [7]. Inside the hepatocytes, the relaxed circular DNA...
(ESCRT) complexes or an ESCRT-independent route through lipid rafts, such as the membrane-associated neutral sphingomyelinase (nSMase) and the ceramide-triggered pathway. As ILVs form, the orientation of plasma membrane receptors or membrane-integrated proteins within the endosome undergoes another ...
Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an...
NTCP: normal tissue complication probability pCR: Pathological complete response PTV: Planning target volume RedCap: research Eletronic Data Capture ROC: Receiver operating characteristic SIB: Simultaneous integrated boost TCP: tumor control probability TME: total mesorectal excision W&W: Watch ...
The fact that structures of SLCs are mobile may well contribute to their druggability, by providing multiple conformations that could be targeted by drugs in alternate modes. Moreover, SLCs can form homo- or hetero-mers, further expanding on their structural heterogeneity, and therefore expanding po...
(a BMP inhibitor). This protocol effectively maintains the expression of functional genes and key transcription factors of PHHs (such as CEBPA, CREBH, HNF4A, PXR, CAR, CYP3A4, CYP2D6, ARG, UGT1A6, and NTCP), while inhibiting the expression of mesenchymal marker genes [39]. This is a...
The analysis of differences in NTCP reduction by IMPT demonstrated a higher benefit of proton therapy in reducing dysphagia for patients with tumors in the upper head and neck area. Further, the clinical benefit of proton therapy for head and neck cancers were recently reviewed by Blanchard et ...
(rcDNA), bind to the NTCP receptor on the hepatocyte membrane and enter the cell via endocytosis; 2) Uncoating and Nuclear Transport: the rcDNA is released and transported into the nucleus via the nuclear pore complex (NPC); 3) cccDNA formation: Inside the nucleus, rcDNA is converted into ...
Also, biological indices based on sums of local dose-response functions like EUD (f = Djk, k > 0), TCP (f = exp(-αD j )) and NTCP (e.g. f = Djk, k≥ 1), as well as DVH penalties (e.g. f = 1/(1 + (D0/D)k), k > 1) can be transformed into this 'standard ...