MRP2 is located in the luminal membrane of small intestinal cells and is responsible for re-secreting bile acids into the intestine lumen. Once in the portal vein, hepatocytes reabsorb the bile acids through the Na+-dependent taurocholic cotransporting polypeptide (NTCP) and organic anion transport...
The life cycle of HBV is illustrated in Fig.1. Briefly, viruses recognize heparan sulfate proteoglycan (HSPGs) on hepatocytes via low-affinity binding and subsequently bind to hepatocyte receptor–sodium taurocholate co-transporting polypeptide (NTCP) by a high-affinity interaction to enter the cell ...
Therefore, any drug-related effect on these transporter and enzyme systems can potentially lead to the accumulation of BAs and/or xenobiotics, which may induce liver injury. In hepatocytes, BAs are taken up by sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) and by organic anion ...
NTCP: normal tissue complication probability pCR: Pathological complete response PTV: Planning target volume RedCap: research Eletronic Data Capture ROC: Receiver operating characteristic SIB: Simultaneous integrated boost TCP: tumor control probability TME: total mesorectal excision W&W: Watch ...
(rcDNA), bind to the NTCP receptor on the hepatocyte membrane and enter the cell via endocytosis; 2) Uncoating and Nuclear Transport: the rcDNA is released and transported into the nucleus via the nuclear pore complex (NPC); 3) cccDNA formation: Inside the nucleus, rcDNA is converted into ...
(NTCP) receptor facilitates entry of the nucleocapsid. Mediated by endocytosis, the nucleocapsid is then transferred to the nucleus via the microtubules [4,5,6,7]. This is followed by nuclear release of rcDNA, which is then repaired to form covalently closed circular DNA (cccDNA). The cccDNA...
A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Med. 2007;23(3–4):115–25. Article PubMed Google Scholar Wu Q, Mohan R, Niemierko A, Schmidt-Ullrich R. Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. ...
(a BMP inhibitor). This protocol effectively maintains the expression of functional genes and key transcription factors of PHHs (such as CEBPA, CREBH, HNF4A, PXR, CAR, CYP3A4, CYP2D6, ARG, UGT1A6, and NTCP), while inhibiting the expression of mesenchymal marker genes [39]. This is a...
Synthetic pathways of bile acids and enterohepatic bile acid circulation. LDL, low-density lipoprotein; LDLR, low-density lipoprotein receptor; NTCP, Na + -dependent taurocholic acid co-transporting polypeptide; OATP, organic anion-transporting polypeptides; BSEP, bile salt export pump; ASBT, apic...
effect of these two treatments [3]. However, the radiation-induced leucopenia has scarcely been included in models estimating the probability of undesirable effects on normal tissues represented by normal tissue complication probability (NTCP) [12]. Among leucocytes, lymphopenia is by far the most ...