First, the PKM2 protein in cancer tissues switches to a low-activity dimer form. Because dimeric PKM2 has low catalytic activity, it increases the formation of glycolytic intermediates by activating other PPP enzymes and glycerol synthesis, as well as creating NADPH. This inhibits the creation of ...
dependent cell proliferation in gallbladder cancer by binding and destabilizing the pyruvate carboxylase (PC) protein [48]. NRCP (lncRNA ceruloplasmin) can function as an intermediary molecule by connecting STAT1 to RNA polymerase II, which leads to upregulation of the key glycolysis enzyme glucose-...
are determined. unlike the total number of candidate pairs, there is no analytic formula to calculate the exact value of nrcp. however, for any given sipe max , the nrcp can be uniquely determined by eqs. ( 10 ), ( 11 ) and ( 12 ). the nrcp for different sipe max values are sho...