To address the unknown molecular basis of their cell-protecting functionality, we used intact human Bcl-2 protein natively residing at the mitochondrial outer membrane and applied neutron reflectometry and NMR spectroscopy. Here we show that the active full-length protein is entirely buried into its ...
especially in the form of polypropylene used in the medical field1,2. In industry, propylene is manufactured via steam cracking of light naphtha and fluid catalytic cracking of natural gas or coal with high energy consumption3,4. However, the nonrenewable nature of fossil fuels has forced ...
The effect of microbes on their human host is often mediated through changes in metabolite concentrations. As such, multiple tools have been proposed to predict metabolite concentrations from microbial taxa frequencies. Such tools typically fail to captu
NMR: Nuclear Magnetic Resonance Spectroscopy α- KGD: α-Ketoglutaratedependent dioxygenase ENNs: Enniatins KIVR: A novel NADPH-dependent 2-ketoisovalerate reductase D-Hiv: D-Hydroxy-isovaleryl SAM: S-adenosylmethionine BEA: Beauvericin HICA: α-Hydroxyisocaproic acid ATMT: The Agrobacter...
age groups (P< .01 after Benjamini–Hochberg, BH correction). The young (3 months) and aged (24 months) groups formed separate clusters in the ordination; however, the old (18 months) group did not form a separate cluster and shared features with both young and aged mice (Fig.5A, Fig...
Being a free radical, NO can react with superoxide anions to form peroxynitrite, a potent oxidizing agent that inflicts damage on surrounding cells and tissues [53]. Superoxide Dismutase (SOD) is a metalloenzyme that catalyzes the disproportionation of superoxide anions, thereby maintaining cellular ...
Analysis of carbon metabolism in Escherichia coli strains with an inactive phosphotransferase system by 13C labeling and NMR spectroscopy. Metab Eng. 2002;4:124–37. CAS PubMed Google Scholar Báez JL, Bolívar F, Gosset G. Determination of 3-deoxy-d-arabino-heptulosonate 7-phosphate ...
jejuni with at least four orders of magnitude greater linear dynamic range and a limit of detection of 10 CFU/mL [60]. Au–Ag core–shell nanoparticles were used by Ding et al. [76] to form aggregates for simultaneous bacterial imaging and synergistic antibacterial activity. The principle of...
Overview of NMR/MRI MRI is the analytical technique of choice to study water and its properties without ionizing or degrading the object. In this section, we will present a brief overview of the basics of NMR and MRI. As we will not explain the physical principles, the interested reader can...
Standardized alternate form of BVMT-R was used for follow up examination. Radiotherapy WBRT was delivered by standard external beam radiotherapy based on two opposing laterolateral equally weighted fields; the multi-leaf collimator was used to shape the fields in such a way that the whole brain ...