Most cells in the malignant clusters mBc1-4 were hyperexpanded clones, while the non-malignant cluster nmBc1-2 predominantly harbored unexpanded cells (single clones) (Fig. 3D–F). Of note, the hyperexpanded clones are spread across all malignant Bc clusters (Fig. 3D–F). The biopsy ...
16GB Application LAPTOP Form Factor X86 Memory Type DDR4 Graphics Card Type Integrated Other attributes Item Condition Used Ports wifi, SATA, USB 2.0, USB 3.0, HDMI Chipset Intel Products Status Used Socket Type SocketA Place of Origin
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Cost data was assigned a Gamma distribution, while QALY scores were represented in terms of a Beta distribution. This probabilistic sensitivity analysis comprised one thousand iterations to derive the final study conclusions. The outcomes of the conducted PSA were presented in the form of a Cost-...
This includes the most frequently encountered form of oxidative DNA damage: production of 7, 8-dihydro-8-oxo-2'-deoxyguanosine (8oxodG) which can lead to ambiguous base pairing (either A or C) during DNA replication. The BER pathway is carried out by two types of enzymes: glycosylases ...
consisting of slate, phyllite, and spotted schist (Berthier1974, Masoudi1997). The intrusive rocks are plutons, stocks, and irregular-shaped ‘patches’ that together with metamorphic country rocks form a band of NW–SE trending outcrops over an elongated area that is 10 km wide and 100 km...
Genetic alteration is the major constituent of somaclonal variation in rice, and which is concomitant with epigenetic alteration in the form of cytosine DNA methylation patterns. In addition, parent-of-origin effect plays a major role in the genetic alteration frequencies of the pair of reciprocal ...
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There is evidence that, even under normal aerobic conditions, most, if not all, replication forks do not proceed from the origin of replication to the terminus without hitting a roadblock, in the form of a damaged DNA template, a nick in the template, a "frozen" protein-DNA complex, or ...
This study aimed to estimate the cost-utility of RI-HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for adolescent and young adult with severe thalassemia in Thailand. Methods A Markov model was used to estimate the relevant costs and health outcomes over the...