28,29,30]. A clinical study revealed that intrathecal administration of antisense oligonucleotides (ASO) can decrease the levels of mutant huntingtin protein (mHTT) in the cerebrospinal fluid of Huntington's disease (HD) patients, and other studies also have...
Presence of conserved protein motifs was evaluated with ScanProsite tool [54], nuclear localization signals (NLS) determined with NLS mapper [55], potential SH2 and SH3 binding sites with ScanProtein [56], and transmembrane sequence motifs with DeepTMHMM [57]. Up-to-date PyV complete genome ...
The 526-amino-acid FUS protein includes a C-terminal non-classical PY nuclear localization signal (NLS) which contains most of the ALS-linked mutations and a N-terminal low complexity, glycine-rich, prion-like domain [4]. Although an important difference from transmissible spongiform encephalopath...
If you have changed the value of NLS_LANG you might have to change the encoding of the PostgreSQL client. You can take a look at the PostgreSQL supported character sets here: http://www.postgresql.org/docs/9.0/static/multibyte.html FORCE_PLSQL_ENCODING To force utf8 encoding of the PL/...
STAT3 consists of six domains [17, 18]: (1) N-terminal domain (NTD), which stabilizes STAT3 entry into the nucleus and DNA binding; (2) Spiral coil structure domain (CCD), which recognizes specific DNA sequences to form STAT3-DNA complexes; (3) DNA binding domain (DBD), which recogniz...
of RNP, and improve the tumor cell targeting of RNP simultaneousl [38]. Nuclear localization signal (NLS) fused Cas9 protein and sgPD-L1 formed RNP, which could target and knockout PD-L1 (Fig.1). NPs could effectively condense RNP by electrostatic interaction to form drug loaded NPs [39...
Ferroptosis is a newly identified form of programmed cell death, distinct from apoptosis and other forms of cell death [9]. It is an iron-dependent cell death characterized by the accumulation of lipid peroxidation and impairment of antioxidant systems, resulting in shrunken mitochondria and reduced...
We provide the rigorous derivation of the wave kinetic equation from the cubic nonlinear Schrödinger (NLS) equation at the kinetic timescale, under a particular scaling law that describes the limiting process. This solves a main conjecture in the theory of wave turbulence, i.e. the kinetic th...
Recent studies have revealed that N-LIP co-folds with part of C-LIP with the help of M-LIP to form the functionally active PAP [10, 12]. In addition, lipins possess a conservative nuclear localization signal (NLS) or poly basic domain (PBD) that has lipid binding ability and is ...
of cationic lipid: DSPC: Cholesterol: DMG-PEG 2000 = 51: 8: 38: 3 for four components in all LNPs. When needed, NLS (MedChemExpress, HY-P1876B) and/or histones (Sigma-Aldrich, H5505) were incubated with DNA or DSPC for 2 h at room temperature. The preparation of LNP/DNA ...