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Alzheimer's disease (AD) is a distinctive form of dementia characterized by age-related cognitive decline and memory impairment. A key hallmark of AD is the irreversible overaccumulation of beta-amyloid (Aβ) in the brain, associated with neuroinflammati
After neutrophil membrane lysis, intracellular pathogens are not directly released to the outside of the cell but can form pore-induced intracellular traps, which coordinate the innate immune response through complement and scavenger receptors to promote neutrophil recruitment to release reactive oxygen ...
The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) homeostasis, and accelerate the deterioration process of articular cartilage in osteoarthritis (OA). In recent years, it has been...
Limitations of EOs in free form and the way nanoformulation can overcome those limitations Full size image In addition, EOs display limited absorption within the avian gut. This is attributed to their susceptibility to degradation within the complex gut environment, their interaction with mucosal cleara...
The main clinical feature of NIID is cognitive impairment; this is one of the earliest (23.1%) and most common (49.4%) symptoms of NIID, with episodic amnesia presenting as the most prevalent form [7]. In a clinical analysis of 54 NIID patients, Sone et al. found that dementia was the...
Currently, dressings are the most common form of cell-based products used in burn therapy [41]. Their shape, however, does not provide a possibility to treat large and complex wounds with a heterogeneous surface profile. Therefore, such technologies as cell spraying and three-dimensional (3D) ...
Once single colonies form, cells were collected and passaged for subsequent rounds of treatment. A total of 10 rounds of gemcitabine exposure were conducted to generate resistant cell lines. Construction of stable transfection cell lines with lentivirus CDCA3-targeted lentivirus (shCDCA3), ENO1-...
In a recent study, AmbiOnp was found to contain a non-toxic super-aggregated form of AmB resulting from the probe sonication-assisted nano-precipitation technique used in SLN preparation.Citation39 The relative bioavailability of AmbiOnp was 1.05-fold with a Cmax of 1109.31–104.79 ng/mL at ...
(MLV). Unilamellar vesicles are further divided into small unilamellar vesicles (SUV) and large unilamellar vesicles (LUV). An onion-like structure is formed in multilamellar liposomes, while several unilamellar vesicles can be formed inside other vesicles and form multilamellar concentric phospholipid ...