Additionally, they identified a compound termed ferrostatin-1 (Fer-1) that obviously inhibits cell death caused by RSL3 by scavenging lipid ROS while not affecting other types of cell death and officially termed this iron-dependent form of cell death as ferroptosis [1]. Subsequently, the study ...
Mechanisms of ferroptosis Ferroptosis was first proposed by Dixon and his colleagues in 2012 and is a different form of regulated cell death (RCD). It was defined as iron-dependent lipid peroxidation [1]. Figure 1 Iron is an essential trace element in the organism with a variety of physiologi...
Ferroptosis is a newly discovered form of cell death that is featured in a wide range of diseases. Exosome therapy is a promising therapeutic option that has attracted much attention due to its low immunogenicity, low toxicity, and ability to penetrate biological barriers. In addition, emerging ev...
Ferroptosis, a distinctive iron-dependent form of regulated cell death induced by the excessive accumulation of lipid peroxides on cellular membranes, is proved to have a dual role in cancer, leading to tumor cell proliferation or elimination [18]. Understanding the regulation of this iron-dependent...
(GFAT1). Subsequent reactions produce the substrate of O-GlcNAc, UDP-GlcNAc. OGT has several isoforms in different cellular compartments: nucleoplasmic OGT (ncOGT) and truncated short OGT (sOGT) are found predominantly in the nucleus and cytoplasm; mitochondrial OGT (mOGT) and ncOGT operate ...
Ferroptosis is an iron-dependent form of death induced by iron accumulation and excessive lipid peroxidation [6, 7]. Cuproptosis is a copper-dependent death in which cells die from copper direct binding to lipoylated component of the tricarboxylic acid (TCA) cycle and aggregating the enzyme, ...
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Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72. https://doi.org/10.1016/j.cell.2012.03.042. Article CAS PubMed PubMed Central Google Scholar Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15:1137–47. https://doi....
GPX4 reduces the endogenous neutralization of PUFAs-OOH to PUFAs-OH, ultimately reducing ROS accumulation. Excess irons are the basis for ferroptosis execution. Circulated iron was combined with transferrin in the form of Fe3+, and then it entered into cells by TFR1. Iron in Fe3+ form was...
Epithelial and capillary cells in the bronchi rupture, forming pulmonary oedema and fibrosis, leading to severe respiratory insufficiency, becoming typical clinical features of patients with severe COVID-19 [1], which is a relatively serious form of disease. The prognosis of patients with COVID-19...