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The most severe form of NCL, infantile neuronal ceroid lipofuscinosis (INCL), is caused by mutations in the CLN1 gene, resulting in a deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). The deficiency of PPT1 causes a specific death of neocortical neurons by a ...
Increasingly, scRNA-Seq studies explore cell populations across different samples and the effect of sample heterogeneity on organism’s phenotype. However, relatively few bioinformatic methods have been developed which adequately address the variation be
First, when a viral DNA invades, CRISPR/Cas9 recognizes the PAMs of invaded DNA and cleaves them into suitable spacers, which are then selected and integrated into the CRISPR loci. Second, the CRISPR loci transcribe and form the effector complexes (crRNP) with the help of RNase III, Cas1...
It shouldn’t remove information of cellular identity to form “average cells” or collapse different cell types or states into one. Second, the network should be robust to the presence of different cell types in hq and lq data or an imbalance in their relative ratios. It should not, for ...
The heatmap displayed the expression profile of these TFs (Fig. 5b and d). Intriguingly, within the coexpression network of TCL, two genes, MbCML27 (Mb13g000970) and MbCaCA (Mb06g009710), were identified, while in the coexpression network of NCL, one gene named MbCBL (Mb04g013530) ...
An Extended Positioning Analysis of a Pre-Service Teacher's Better Life Small Story The analysis of narrative data in applied linguistics has focused to varying degrees on their content, form, and context, with content and thematic analyse... GARY BARKHUIZEN - 《Applied Linguistics》 被引量: ...