The proliferation of satellite cells provides a sufficient source of new myonuclei for muscle repair. Satellite cells differentiate and fuse to each other or with existing damaged fibers for repair to form new myofibers [4, 22]. The fundamental morphological characteristics are that newly formed ...
Novel regulatory sequence − 82/-62 functions as a key element to drive the somite-specificity of zebrafish myf-5. Dev Dyn. 2003;228:41–50. Article CAS PubMed Google Scholar Lee HC, Huang HY, Lin CY, Chen YH, Tsai HJ. Foxd3 mediates zebrafish myf5 expression during early so...
utilized depending on the cellular context, RNA secondary structure, or effector proteins associated with a specific miRNA:mRNA pair [20]. For example, transcription of a miRNA from different promoters altered the specific mechanism of repression; suggesting that the nuclear history of a miRNA may i...
The proform of MMP-9 (92 kDa) and MMP-2 (72 kDa) and their cleaved active forms are indicated. e In vitro H3 cleavage assay using core histone substrates in the presence or absence of active recombinant MMP-2 or MMP-9. Western analysis was performed to detect the H3cl product using ...
Sneakily, heavy drops ofwater fell incessantly on each form, including us. Sun and water calibrate prominent dynamics in the Amazon letting unique lifestyles to be set into motion in the forest. Life takes on so many colors and profiles in the forest that biodiversity seems endless. Such a ...
Alveologenesis is the final stage of lung development to form air-exchanging units between alveoli and blood vessels. Genetic susceptibility or hyperoxic stress to perturb this complicated process can cause abnormal enlargement of alveoli and lead to bro
Small-molecule inhibitors of Janus kinases (JAKi) are clinically efficacious in patients with RA. However, the isoform-specific action of each JAKi is difficult to assess, since JAKs form heterodimeric complexes with cytokine receptors. We assessed the effects of several JAKi on GM-CSF-primed ...
Amino-acid sequences of the N-terminal (a) and C-terminal domains (b) as well as of the HLH domains (c) of the human Id proteins (for Id1 and Id3 the C-terminus found in a spliced form is reported as Id1′ and Id3L).dStructures of the homodimers of the fragments Id2 30–82...
Myf5 is subjected to multiple phosphorylations in Xenopus mitotic egg extracts, that tightly control its stability: phosphorylation of the protein leads to its ubiquitylation by an E3 distinct from APC/C, and its subsequent degradation by the proteasome. However, a hyperphosphorylated form of Myf5 ...
Schematic representation of a biomaterials-based delivery system. The motor neuron, skeletal muscle, and neuromuscular junction (NMJ) contribute to a complete neuromuscular functional unit. The motor neuron axon branches as it comes into contact with the skeletal muscle to form a single NMJ with each...