Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes increase, estimate
Most importantly, the superior performance of MAGPIE in highly imbalanced validation dataset, as well as variants with low population allele frequency highlights its advantage in clinically relevant applications of interpreting VUS for individual patients, where the model is typically applied to identify l...
We test a novel ‘weight scarring’ hypothesis which suggests that past obesity is associated with impairments in current psychological well-being and this increases risk of negative physical health outcomes associated with obesity. Across two nationally representative studies, we tested whether past obes...
In this regard, traditional Chinese medicine (TCM) that have a long history of clinical use may hold great promise in delaying or halting the progression of the patient’s symptoms (e.g., loss of memory and impaired cognition). TCM is well-known for its multi-target properties as each ...
After addressing modifiable factors, children whose disease remains poorly controlled on high doses of medication form a heterogeneous group considered to have ‘severe’ asthma phenotypes [4], and are eligible for step-up therapies. These include long-acting muscarinic antagonists, oral corticosteroids...
Traditional Chinese Medicine (TCM) has been widely used in the treatment of various diseases for millennia. In the modernization process of TCM, TCM ingredient databases are playing more and more important roles. However, most of the existing TCM ingredient databases do not provide simplification fun...
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At the start of their first year, all students in the School of Medicine are assigned a peer-mentor who guides them through the orientation period. This orientation period includes social activities as well as academic guidance for the first few weeks of university. Our overarching research ...
While particular strains within the Bacillus species, such as Bacillus subtilis, have been commercially utilised as probiotics, it is critical to implement screening assays and evaluate the safety to identify potential Bacillus probiotic strains before c
In addition, lotus root can be used as an ingredient in Chinese herbal medicine [4], which is beneficial for human health. Generally, the storage organ is formed underground, and adventitious roots (ARs) are necessary for water and nutrient uptake owing to degeneration of the principal root. ...