performed transcriptional profiling of TNBC tumors and categorized TNBC into six molecular subtypes, which displayed differential responses to chemotherapy. These subtypes were Basal-like 1 (BL1), Basal-like 2 (BL2), Immunomodulatory (IM), Mesenchymal (M), Mesenchymal stem-like (MSL), and Luminal ...
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The molecular subtype of TNBC. At present, TNBC is mainly divided into the following categories, including BL1/2, IM, ML, MSL, and LAR. (The molecular subtype of TNBC was adapted from Fig.2in [23]) BL1: basal-like 1, IM: immunomodulatory, ML: mesenchymal-like, MSL: mesenchymal stem-...
In cases where the extracted data were incomplete or unavailable in a usable form, attempts were made to contact the authors of the selected papers to obtain the necessary information. Risk of bias assessments The risk of bias in the included studies was evaluated using ROB2 tool for RCTs ...
During the time between the 24 to 48 hour APF stages, the imaginal discs are still undergoing morphogenesis, but are close to their final adult form. The wings, leg muscles, abdominal bristles, abdominal muscles and internal genital ducts are all well formed, while further development of the ...
assays and pathways; the development of predictive models for biological activity and other biological endpoints; data mining of chemical and biological data points; the availability of journal articles in electronic form, and associated indexing (such as in PubMed) and text mining of their content....
this implies transposition in the germline cells that will form the next generation. Sexual reproduction might be instrumental for the propagation of mainly deleterious TEs [15,16,17]. Indeed, in asexual populations, TEs might not be able to spread and tend to be eliminated if no horizontal tra...
pictures allows filling most of the gaps. The picture is certainly far from optimum but the best shot I found of this region. –Dr. Norbert Gasch – This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows evidence of wind deposition of fine sediment in the form of drifts ...
The genetic analysis of patient data with TNBC has revealed distinct subtypes, such as basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem-like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR) subtypes [45]. Research has also uncovered regional geneti...
Map of mutations and PTMs of p53 generated using cBioPortal tools (http://www.cBioPortal.org) and curated manually Full size image Mediators involved in ubiquitination, such as MDM2, MKRN1, MSL2, and E4F1, exhibit distinct functionalities; MDM2 and MKRN1 are associated with proteasomal degrad...