The current studies found down-regulation of MRPL12, which would regulate mitochondria-mediated cell death and respiration [39, 40]. VDAC1 and VDAC2 forms a channel through the mitochondrial outer membrane with a weak anion selectivity at the open state and a cation-selectivity at the close ...
Our article provides a resource in form of module based gene annotation tables that could form the starting point of future biological validation studies. Depending on their function, these candidate genes can be tested by RNAi knock down, viral infection in order to increase the efficiency of ...
plant and various algal cells. In all cases, distinct small and large ribosomal subunits exist that join together during the translation initiation process to form mature ribosomes capable of protein synthesis. (See references [3–6] for general reviews of ribosomal structure and function.) The pr...
we performed high-throughput sequencing of poly(A) enriched RNA from infected and non-infected (control) cells. To obtain RNA for transcriptional studies ofM. marinuminfectedD. discoideum, we used a high multiplicity of infection (MOI of 200) in order...
The activity of TCA cycle metabolism decreases with age, leading to reduced levels of NAD + restoration [7,23,24,25]. NAD + plays a central role in controlling hundreds of pathways in both energy metabolism and cell survival. Both NAD + and its reduced form are involved in ...
genomes is therefore required to form a functional mitochondrion. Studies of the repertoire of proteins comprising the mitochondrion (mitochondrial proteome or mitoproteome) have revealed that this organelle is a structural and functional amalgam of proteins having different phylogenetic origins: an ...
The advances in gene annotation for OGS2 are notable today, however as gene evidence accumulates in the future, new and improved gene sets will need to be constructed until a verifiably complete and biologically accurate gene set is produced. Transcriptomic data in the form of high quality and ...
(94.1 %) of these are expressed in the human brain (Fig.1), five of which encode mitochondrial proteins (PRODH,SLC25A1,MRPL40,TXNRD2,TANGO2). In the zebrafish, there were five genes (PRODH,SLC25A1,CLDN5,SEPT5,COMT) where multiple putative homologues were identified, likely due to ...
(Fig.1). A remarkable example was reported forMRPL18encoding mitochondrial ribosomal protein L18 [48]. Here initiation at a CUG codon occurs downstream of the main AUG codon under heat shock stress conditions. The truncated ribosomal L18 protein lacks a mitochondrial localization sequence and is ...
Our article provides a resource in form of module based gene annotation tables that could form the starting point of future biological validation studies. Depending on their function, these candidate genes can be tested by RNAi knock down, viral infection in order to increase the efficiency of ...