In AD, tau becomes hyperphosphorylated and aggregates to form paired helical filaments, a major component of NFTs within the neuronal cytoplasm. As the disease progresses, the gradual spread of tau pathology throughout brain regions has been suggested to be caused by the transfer of abnormal ...
3D multicellular coculture model: Patient-derived tumor cells are co-cultured with hESC/hIPSC-derived brain organoids or tumor microenvironmental (TME) cells to form 3D multicellular systems. All these systems can be subsequently transplanted into immunocompromised mice to form tumors in vivo. Full ...
A cross-sectional study was conducted in a sample of 389 older individuals with complaints of memory decline. The instruments included the Neuropsychiatric Inventory, the Mini Mental State Examination, and the 36-item Short Form Health Survey. Data was analyzed using network analysis and mediation an...
Conclusions:CV and NPi evaluate two different aspects of the PLR; NPi and CV are both unlinked to ischemic stroke outcome at discharge, maybe due to the sample size. Further studies are required to the determine the utility of CV and NPi in the prognostication of ischemic stroke outcome. ...
These medications later undergo re-oxidation to form disulfide bonds. However, this approach is restricted to drugs soluble in lipids and faces difficulties expanding its application. Furthermore, there are cases where the inclusion of reducing agents can lead to potential toxicity [86]. Thermal ...
An additional type of artefact not related to metal implants was observed in the form of missing bone: Bone gaps (type 3 on Fig. 1): These artefacts are regions of the skull that appear as bone resection sites in the sCT images, despite the clear presence of bone in all MR images. Th...
Furthermore, the dead flowers, leaves, and fruits of perennial crops contain large amounts of mycelium that can form conidia and establish infection. In aging cultures, B. cinerea also produces large quantities of microconidia from phialides, which predominantly serve as spermatia. The sexual ...
There was no change in the choice of and prioritization of outcome measures in the course of the trial. From the time the subject signs the informed consent form, all adverse events (AEs) that occurred were captured on case report forms and included in the summaries. AE evaluation comprised ...
All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/disclosure-of-interest/ and declare no additional support from any organisation for the submitted work, other than that declared in the manuscript; no financial relationships with any organisations that might have ...