ECs, as a key component of angiogenesis, are also regulated by EVs generated from ADSCs. Mmu_circ_0001052 in exosomes from ADSCs suppresses the expression of miR-106a-5p in human umbilical vein endothelial cells (HUVECs), ultimately promoting angiogenesis and wound healing in DFU [130]. In...
Firstly, under the influence of different cell types and stimuli factors, the cell membrane forms inward protrusions of varying shapes and sizes through "inverted budding." Subsequently, these protrusions gradually expand and detach from the parent cell membrane to form early endosomes [37]. Then,...
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–72. Article CAS PubMed PubMed Central Google Scholar Su L, Zhang J, Gomez H, Kellum JA, Peng Z. Mitochondria ROS and mitophagy in acute kidney injury. Autophagy. 2023;19(2):401–14. Song S, ...
One of the few pathways downregulated by ischemia was lipid metabolism (R-MMU-556833). Selected pathways are shown in Fig. 1E (see full list in Additional file 2: Table S1). Fig. 1 Ischemia-induced translatomic changes in mRNA obtained from the PdgfbicreER:Rpl22HA mice. A Mice were ...
The introduction of precision medicine may offer significant prospects to improve access as a form of preventative and diagnostic care and therefore equity with respect to health care services for racialized communities in Canada. Barriers for racialized communities to access these health innovations, howe...
Circular non-coding RNAs (circRNAs) are a type of regulatory non-coding RNAs generated by back-splicing of pre-mRNAs to form a circular covalently closed structure. These circRNAs are resistant to degradation by RNA enzymes and maintain stable functionality within the body [6, 7, 8]. CircRNAs...
Pfizer Announces Positive Top-Line Data for Full Season Two Efficacy of ABRYSVO ® for RSV in Older Adults.
To ensure protection of protected resources and the underlying secure OS, the vGPUs have a secure L2 cache and Memory Management Unit (sMMU) which maps directly to the ARM system MMU and supports TrustZone implementations and the CoreLink Cache Coherent Interconnect and Dynamic Memory Controller in...
Taken together, these results show possible mechanisms involving MTs, mitochondrial processes and the UPR by which individuals might maintain cognition despite the presence of AD pathology.Introduction Alzheimer disease (AD) is the most common form of dementia, affecting 47 million individuals worldwide ...
Studies have shown that hyperphosphatemia can influence the fate of VSMCs by transporting phosphate into VSMCs in a phosphate transporter (Pit1/Pit2)-dependent, independent (in nanoparticle form) or calpain particle (CPP) manner, thereby activating the intracellular pro-calcification signaling ...