Four out of five people living with osteoarthritis (OA) also suffer with at least one other long-term health condition. The complex interaction between OA and multiple long-term conditions (MLTCs) can result in difficulties with self-care, restricted mobility, pain, anxiety, depression and reduce...
Study enrolment procedures consist of the informed consent process, authorization to release personal health information for the research, completing a “locator” form to share details for future contact with the participants, and completing the baseline assessment through self-administration via an ...
Because the historical evolution in form and content of “Data” and “Algorithm” concepts has a poignant bearing on the issue, it is worth exploring the intellectual history of these two concepts in order to illustrate how they are intertwined. A curious fact about our data-obsessed era is ...
We also included disability in activities of daily living (ADL disability). ADL disability was defined as having needs for assistance or difficulty in one or more of the ten items in Barthel Index [25]. Nutrition status was evaluated with the Mini Nutrition Assessment-Short form (MNA-SF) [...
Dr. Craig showed multiple use cases of MLT for genetic medicine. The company is working on targeted CFTR super-exon insertions to correct recessive mutations in cystic fibrosis, as well as the production of cancer-targeting CAR-T cells. Toward in vivo therapeutics, she presented data on cell-...
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Folstein MLT, Peter I, Buell J, Arsenault L, Scott T, et al. The homocysteine hypothesis of depression. Am J Psychiatry. 2007;164(6):861–7. Article PubMed Google Scholar Yu J, Xue R, Wang Q, Yu H, Liu X. The effects of plasma homocysteine level on the risk of three major ps...
This procedure fits a log-logistic model with the following form: f\left(x;b,c,d,e\right)=c+\frac{d-c}{1+exp(b(\mathrm{ln\, }x-\mathrm{ln\, }e))} Above, the lower and upper asymptotic limits of the response are encoded by c and d, respectively. b captures the steepness ...
In both invivoand in vitro experiments, research has demonstrated that EVs play a pivotal role in promoting angiogenesis and altering vascular permeability [161]. Among these mechanisms, sprouting stands out as a vital form of neoangiogenesis [162]. EVs rich in clathrin light chain A (CLTA) ha...
Tumor-associated neutrophils (TANs) aggregate in the TME of the primary lesion, blood, and distant metastatic organs, where they form the premetastatic niche (PMN) [15]. During hypoxia, the expression of HIF in neutrophils increases, causing them to polarize toward N2, which contributes to an...