SMOTE, unbiased decoy selection and SMILES enumeration were applied to improve the performance of the ML and DL models when the dataset was severely imbalanced. A dataset containing more than 4000 USP7 ligands was first constructed manually. This study has the following two objectives: (i) We ...
While learning curves have been explored in a variety of small-scale applications with classical ML [15,16,17,18], only a few recent studies have applied DL methods to large benchmark datasets in vision and text applications [19,20,21]. To the best of our knowledge, learning curves of ...
However, in clinical practice of genetic diagnosis using WES, different types of mutations and mechanisms should be considered simultaneously to identify the pathogenic mutation. With the development of machine learning (ML) and deep learning (DL), many computational methods using ML or DL have been...
3c). Taking the negatively charged wall of the microchannel as an example, when the liquid contacts the negatively charged wall of the microchannel, the cations in the liquid gather on the wall of the microchannel to form a thin electric double layer (EDL) (0.1 nm-10 nm). Under the ...
In the MLPerf Inference v3.0 round, NVIDIA submitted results on several products, including NVIDIA H100 Tensor Core GPUs (both SXM and PCIe add-in-card form factors) based on the NVIDIA Hopper architecture, the recently announced NVIDIA L4 Tensor Core GPU powered by the NVIDIA Ada...
We recently published evidence to suggest that two populations of stem cells including very small embryonic-like stem cells (VSELs) and ovarian stem cells (OSCs) in ovary surface epithelium (OSE) undergo proliferation/differentiation, germ cell nests (GCN) formation, meiosis and eventually differentia...
In one dimension of RAMI 4.0, the different functionalities of a factory or machine are arranged in the form of hierarchical levels from IEC 62.264. IEC 62.264 is an international standard for the integration of enterprise control systems [Citation65], which was extended in RAMI 4.0 with the ...
In biodesulfurization (BD) at haloalkaline and dO2-limited conditions, sulfide-oxidizing bacteria (SOB) effectively convert sulfide into elemental sulfur t
Non-classical HLA class I molecules (HLA-E, -F, −G) have a similar protein structure to that of the classical HLA class I alleles and also require a bound peptide in the binding groove to form a stable complex. However, they are characterized by few allelic polymorphisms and play a ...
All three fungi form appresoria (specialized infection structures formed by germinating spores) to enter the plant cell. Expression studies have demonstrated that secondary metabolism pathways are active during the infection process[38], suggesting that the increased number of CYP65 and CYP68 family ...