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“To move things is all that mankind can do, and for this the sole executant is a muscle, whether it be whispering a syllable or felling a forest.” This quote from Charles Sherrington describes the crucial role of the neuromuscular system in the biology of humans and other vertebrates. Ske...
In addition, miR-142a-5p is an important regulator of denervation-induced skeletal muscle atrophy, which can induce mitochondrial dysfunction, mitophagy and apoptosis by targeting MFN1 [184]. Spinal cord injury is a unique form of disuse atrophy in which paralysis and disruption of the central ...
inhibition of the androgen signaling pathway has emerged as a major therapeutic approach against tumors, where androgen levels are reduced by using hormones. Androgen deprivation therapy (ADT) is the name given to this treatment [26]. Hormone therapy such as ADT is highly effective in the ...
https://doi.org/10.1093/annonc/mdx310. Article PubMed CAS Google Scholar van Harten W, Ijzerman MJ. Responsible pricing in value-based assessment of cancer drugs: real-world data are an inevitable addition to select meaningful new cancer treatments. Ecancermedicalscience. 2017;11:ed71. https...
In this article, we will build a subscription wall for your MDX blog using Clerk, an easy-to-use auth provider, and integrate it into our blog using MDX and ContentLayer. November 1, 2023 Reviews Typescript The Rise of Next.js: Why It's the Full-Stack Framework of Choice for Modern ...
[118,119]. CRISPR-Cas tools can be delivered in the form of DNA, mRNA, or ribonucleoprotein complexes (RNP) through ex vivo or in vivo approaches. Various robust methods have been established to deliver genome editing reagents ex vivo, some of which have been used in multiple clinical ...
Interestingly, there is only a low incidence (< 1% by area) of myofibre necrosis in the affected dysferlin-deficient muscles, even in mice up to 19 months of age [12]; instead, some form of proteolysis is suggested as the primary cause for the loss of dysferlin-deficient myofibres [13...
The canonical expression of different subtypes of laminin protein chains is conducive to regeneration of damaged skeletal muscles. Laminin-1 can maintain the adhesion of muscle fibers on basal lamina, improve muscle performance of mdx mice, relieve degeneration and inflammation of skeletal muscles, short...
In this article, we will build a subscription wall for your MDX blog using Clerk, an easy-to-use auth provider, and integrate it into our blog using MDX and ContentLayer. November 1, 2023 Reviews Typescript The Rise of Next.js: Why It's the Full-Stack Framework of Choice for Modern ...