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Multiplicative interaction was assessed by adding interaction terms to the Cox models. Several sensitivity analyses were performed to verify the robustness of the results. First, to minimize the influence of reverse causation, we excluded depression and anxiety cases that occurred in the first year of...
Genome sequencing of large biobanks from under-represented ancestries provides a valuable resource for the interrogation of Mendelian disease burden at world population level, complementing small-scale familial studies. Here, we interrogate 6045 whole ge
With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and interpretation of spatial cellular landscapes. Herein, we introduce SpaDo, a tool for multi-slice spatial domain analy
Like other cancers, colorectal cancer cells act very smart and complex because they live in a microenvironment where cancer behavior results from the interaction of several factors, including immune cells, cancer cells, connective tissue cells and etc. Due to the heterogeneity of this cancer and to...
For example, the study believes that women living in cities and with higher education are likely to choose primary medical institutions for medical treatment [21].In rural areas of China, elderly with low income may choose to doctor themselves [22]. Marriage can promote young people to form ...
IgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis exclusively relies on invasive renal biopsy, and specific treatment is deficient. Thus, our study aims to identify potenti
by the mpileup function of SAMtools. Each was used to call variants in tumor-only mode, meaning mutations were called relative to the hg19 genome. Each program outputs some form of variant call file (VCF), from which we extracted SNV calls along with associated information provided by the ...
of the eighteenth century, but in more modern times, Dr. Albert Sabin developed the oral polio vaccine jointly with his Soviet Russian counterparts during some of the toughest years of the Cold War (Hotez2014,2021). I aspired to replicate this accomplishment in some twenty-first century form....
However, only a few studies verified its potential in older adults, especially with vulnerable populations such as migrants. This article presents the protocol of the MEDITAGING study, which is the first to investigate the MBSR effects in migrants aged ≥55 in comparison to a health promotion ...