b Cartoon representation of the tertiary structure of MCL-1 (PDB ID: 6QB3). The BH core of MCL-1 is composed of eight α helices. The BH1 (blue), BH2 (yellow) and BH3 (red) domains form a hydrophobic groove called the BH3-binding groove. c Surface representation of the BH3 ...
as it plays a pivotal role in many defining features of malignant cells [7,8,9,10]. Despite the significant amount of progress made with the development of AKT inhibitors, the therapeutic benefit gleaned from these drugs, mainly in the form of dual therapies, is variable. Toxicity resulting ...
There are many studies on XIAP (X-linked Inhibitor of apoptosis) as a target and prognostic biomarker in other cancer types. For example, use of XIAP BIR domain as a target for discovering antagonists [36,37]; the role of XIAP in mitochondrial membrane permeability as a target for cancer t...
The graph comprised 24,808 nodes connected by 1,476,632 edges and was subsequently clustered using the Markov clustering algorithm (MCL) at an inflation value (which controls the granularity of clustering) of 2.2. This resulted in 378 clusters containing more than 6 nodes. Transcripts in ...
[148], resulting in constitutively cyclin-D1 expression and abnormal proliferation. In a fraction of MCL patients lymphoma cells express the SOX11 transcription factor, which is associated with minimal Ig SHM, higher genetic instability and a more aggressive clinical course [149,150]. Primary MCL ...
ATM is a tumor suppressor gene that is inactivated in 2–8% of common epithelial cancers, including breast and pancreatic [122,163]. ATM is also biallelically lost in nearly all T cell prolymphocytic leukemias (T-PLL), 50% of mantle cell lymphomas (MCL) and 5–10% of chronic lymphocytic...
WGD duplication subgraphs form a connected network The empirical WGD network, formed by all nontrivial DSs, is made of one large connected component and very few small ones. Using the one-shot duplication model, we considered the probability, in a random realization, that the WGD network formed...
benthamiana, the presence of an AtSOT did improve the accumulation of BGLS significantly [6]. PAPS as limiting co-substrate All known sulfotransferases utilize 3'-phosphoadenosine-5'-phosphosulfate (PAPS) as the activated form of sulfate, and the last step of the glucosinolate pathway is no ...
Table 1 The 20 largest Bgh protein families according to MCL analysis Full size table Predicted subcellular localization of Bghproteins We performed an analysis of potential subcellular localization for the 6,495 conceptual Bgh proteins using ProtComp (Version 9.0), which combines several methods for...
Proapoptotic B-cell lymphoma 2 (BCL-2) antagonist/killer (BAK) and BCL-2-associated X (BAX) form toxic mitochondrial pores in response to cellular stress. Whereas BAX resides predominantly in the cytosol, BAK is constitutively localized to the outer mitochondrial membrane. Select BCL-2 homology...