Several other DUBs have been implicated in various disease processes in which they are changed by mutation, have altered expression levels, and/or form part of regulatory complexes. Specific examples of DUB involvement in various diseases are presented. While no specific drugs targeting DUBs have ...
YB-1 is a multifunctional protein that affects transcription, splicing, and translation. Overexpression of YB-1 in breast cancers causes cisplatin resistance. Recent data have shown that YB-1 is also overexpress in colorectal cancer. In this study, we te
One of the essential processing events during pre-mRNA maturation is the post-transcriptional addition of a polyadenine [poly(A)] tail. The 3'-end poly(A) track protects mRNA from unregulated degradation, and indicates the integrity of mRNA through recognition by mRNA export and translation machi...
Altogether, these data show that the binding affinity of the bufadienolides and cardenolides under study is usually higher for the α2β1 and α3β1 than for the α1β1 NaK complex, excepted for hellebrin and its aglycone form, hellebrigenin, with hellebrigenin being as potent as hel...
Unpaired loop and bulge regions can be unstructured or form tertiary structural modules, both of which can be readily recognized by RBPs. In contrast, double-stranded RNAs, in general, do not provide good platforms for RBP binding: structured RNA regions captured by gPAR-CLIP generally had low...
form and phenotype is expressed as proteins, which have not only diverse catalytic and structural functions, but also regulate the activity of the system in various ways. This is largely true in prokaryotes and presumed also to be true in eukaryotes [1]. But one of the great surprises of ...
Protein kinases and phosphatases regulate protein phosphorylation, a critical means of modulating protein function, stability and localization. The identification of functional networks for protein phosphatases has been slow due to their redundant nature
The core circadian machinery involves a transactivating CLOCK/BMAL1 heterodimer, which induces the transcription of a large number of genes, including the cryptochrome (CRY1 and CRY2) and period (PER1, PER2, PER3) genes that form a complex that leads to a negative feedback loop suppressing ...
of expression patterns because their products form pathways. The glycolytic pathway is located in the cytosol and consists of a sequence of ten steps catalyzed by 22 different gene products, some of which are isozymes. The product of glycolysis (pyruvate) serves as starting material for the ...
S. schenckii is dimorphic and can grow either in a mycelial form with long branching filaments at 25°C or in the form of spherical ovoid yeast cells which are typically found in animal hosts [1]. In nature or in animal hosts, fungal cells must respond efficiently to changing environmental...