Caspase-1 promotes TAM differentiation by cleaving PPARγ at Asp64, which translocates into the mitochondria where it directly interacts with medium-chain acyl-CoA dehydrogenase (MCAD). This binding event attenuates MCAD activity and inhibits fatty acid oxidation, thereby leading to the accumulation of...
Colorectal cancer ranks as the third most prevalent form of cancer in the population and is well recognized as a significant global public health concern. Colorectal cancer has the potential to metastasize from the colon’s surface to the colon tissue and other organs such as the liver, prostate...
They are divided into core hallmarks, major phenotypes needed to form a cancer, and the enabling hallmark of genomic instability, a molecular mechanism driving the acquisition of the core hallmarks. In the most recent update to this system [2], metabolism is described as an emerging hallmark ...
Lipid countertransport mediated by ORP10 at the ER-endosomal MCSs plays a crucial role in regulating retrograde membrane transport. ORP9 and ORP10 form dimers and, along with VAP, establish the ER-endosomal MCS in a process dependent on PI4P ORP10 facilitates the transfer of PS from the endo...
Diazepam and midazolam inhibited proliferation of murine MCs as well as pro-inflammatory mediator release from these cells [17]. With respect to systemic MC activation disease (MCAD) [17, 18], the clinical efficacy of the BDZs flunitrazepam, diazepam, bromazepam, and midazolam for the treatment ...
(MCA) data involving 201,764 cells from 32 tissues were also selected (https://figshare.com/articles/MCADGE_Data/5435866). Unannotated cells were further excluded during preprocessing. Specifically, we extracted six typical datasets: human bladder, human kidney, human fetal pancreas, mouse bladder...
Severity of symptoms, during the previous 3 month period and during and post TCM therapy at different times as indicated were recorded in a patient history form and patient files. Blue bars indicate reaction scores during the 3 months before TCM. Green bars indicate symptom scores during and aft...
Its neutralizes several free radicals [105], reduces the oxidized form of vitamin C and GSH, prevents the synthesis of free radicals by forming stable complex with the catalyzers Mn2+, Cu2+, and Zn2+and chelating Fe2+[106] and limits the inflammation through the inhibition of NFkB [107]...
Marketing is defined as “any form of commercial communication or message that is designed to, or has the effect of, increasing the recognition, appeal and/or consumption of particular products and services.” [8] It includes any activity that “acts to advertise or otherwise promote a product...
MB-231 cells, compound24elicits ERRα degradation with a DC50in the low nanomolar range and achieves nearly full degradation at 100 nM. Notably, Peng et al. demonstrated that the PROTAC-induced loss of ERRα resulted in decreased expression of the downstream genes ATP5B, MCAD, and PDK4....