Caspase-1 promotes TAM differentiation by cleaving PPARγ at Asp64, which translocates into the mitochondria where it directly interacts with medium-chain acyl-CoA dehydrogenase (MCAD). This binding event attenuates MCAD activity and inhibits fatty acid oxidation, thereby leading to the accumulation of...
detected in both patients was located in intron 7, which is a common pathogenic variant in Asian populations, and can lead to the skipping of exon 8, resulting in the formation of a premature stop codon at amino acid position 311 and ultimately generating a truncated form of the pendin ...
will use to facilitate discussions in the MCAD Integration Design Workshop. The document is very preliminary and will be modified based on your feedback. If you have time, please review with your teams ahead of the meeting. 这我们在MCAD综合化设计车间将使用促进讨论的一个最初的草稿MCAD SW规格...
Colorectal cancer ranks as the third most prevalent form of cancer in the population and is well recognized as a significant global public health concern. Colorectal cancer has the potential to metastasize from the colon’s surface to the colon tissue and other organs such as the liver, prostate...
MB-231 cells, compound24elicits ERRα degradation with a DC50in the low nanomolar range and achieves nearly full degradation at 100 nM. Notably, Peng et al. demonstrated that the PROTAC-induced loss of ERRα resulted in decreased expression of the downstream genes ATP5B, MCAD, and PDK4....
Given its major role in maintaining whole-body glucose homeostasis, skeletal muscle IR precedes the onset of type 2 diabetes [2]. Lipid-induced IR is the most important form of IR in the skeletal muscle [1, 3, 4], for which ageing is a risk factor [5]. Different mechanisms have been...
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Nielsen KB, Sorensen S, Cartegni L, Corydon TJ, Doktor TK, Schroeder LD, Reinert LS, Elpeleg O, Krainer AR, Gregersen N, Kjems J, Andresen BS: Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from ...
Diazepam and midazolam inhibited proliferation of murine MCs as well as pro-inflammatory mediator release from these cells [17]. With respect to systemic MC activation disease (MCAD) [17, 18], the clinical efficacy of the BDZs flunitrazepam, diazepam, bromazepam, and midazolam for the treatment ...
Its neutralizes several free radicals [105], reduces the oxidized form of vitamin C and GSH, prevents the synthesis of free radicals by forming stable complex with the catalyzers Mn2+, Cu2+, and Zn2+and chelating Fe2+[106] and limits the inflammation through the inhibition of NFkB [107]...