When aggregating cytokine profiles across all three time points the subset of IL-13, 10 and 23 measured at rest were again retained and additional context was recruited in the form IFN-γ at peak effort and IL-15 post-exercise. Used together, these cytokines measured across all three phases ...
d, Additional file 1: Fig. S1a,b), predicted to cause a frameshift leading to loss of the highly conserved C-terminal 69 amino acids of the TLDc domain of all OXR1 isoforms. Western blot of control cells showed a strong band corresponding to the OXR1B protein that was absent in the...
The formation of a mature messenger RNA (mRNA) is a multi-step process. In higher eukaryotes, variations in each of these steps, including alternative transcription initiation, differential splicing of exons, and alternative polyadenylation site usage, change the content of the mature transcript. The...
Size selection was performed via a BluePippin (Sage Science, Beverly, MA) to construct a cDNA library of size > 4 kb. The same amount of non-selected cDNA and > 4 kb cDNA were combined to form Iso-Seq library for SMRT sequencing. Iso-Seq data processing with standard ...
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Advanced schistosomiasis is the most severe form of schistosomiasis japonica, a serious neglected tropical disease with considerable morbidity endemic in China, Indonesia, and the Philippines [1,2,3]. Lack of timely and effective treatment or long-term repeated infections can lead chronic schistosomiasis...
cAMP is sensed by cAMP-receptors, which form an unusual family of GPCRs [2]. Signalling via cARs is mediated by Gα2, one of the 14 Gα proteins of D. discoideum, however, many cAMP responses are also independent of G proteins [3]. Several other signaling molecules such as cell ...
[17]. Increasing the endogenous IAA content induces cell differentiation to form ARs [18], and anything that affects IAA synthesis and transport can alter the development of the lateral roots [19,20]. The crosstalk between ethylene and IAA in regulating root formation shows that the AR ...
All these factors form an immunosuppressive tumor environment to promote the immune escape of tumor cells. Structural biology of IDO1 Human IDO1 (hIDO1) is an α-helical dioxygenase protein containing a small N-terminal domain (NTD, residues 1–154) and a large C-terminal domain (CTD, ...
After the Xiaolangdi Reservoir (XLDR) was put into operation, new water and sediment conditions have improved the silting condition of the Lower Yellow River (LYR), but against this background, the flow capacity of the LYR has become more complex. In thi