In this context, CAR-T-cell therapy, an innovative form of immunotherapy, presents new possibilities for treating T-cell malignancies by specifically engineering a patient’s T cells to recognize and eliminate cancer cells. However, the development of CAR-T-cell therapies targeting T-cell ...
In the collection stage, CoT prompts guide the LLM to automatically gather various reasoning chains that form the foundation of the repair knowledge. In the repair stage, sample selection is performed for few-shot learning, with interactive feedback from the LLM. This approach significantly improves...
Bioactive peptides and proteins (BAPPs) are functional molecules with unique amino acid sequences that are involved in a plethora of biological processes, including biocatalysis, immunomodulation, activation/inhibition of signaling pathways, and the regulation of cellular fate and behavior [1,2]. Thus...
making them valuable in drug delivery, tissue engineering, and antibacterial dressing. The diverse design of polymer chains and self-assembly techniques allow different side chains and secondary structures, enhancing their biomedical potential. However, the traditional solid powder form of polypeptides...
Recently, with the rapid development of natural products and nanotechnology, in order to solve their respective problems, the two have carried out reasonable cooperation to obtain better therapeutic effects, which has become the focus of attention [25]. As a new type of pharmaceutical dosage form,...
Komagataella phaffii, a type of methanotrophic yeast, can use methanol, a favorable non-sugar substrate in eco-friendly bio-manufacturing. The dissimilation pathway in K. phaffii leads to the loss of carbon atoms in the form of CO2. However, the ΔFLD strain, engineered to lack formaldehyde de...
All participants completed an informed consent form that included the purpose of the study before the start of the study. Participants demographics A total of 48 participants were enrolled in this study. They were randomly divided into the LBL group (n = 24) and SPOC + PBL group (...
2013). A drawback of BNNT is its tendency to form large clusters in aqueous media, which hinders its direct use for cell studies. Strategies have been formulated with a wide range of polymers such as glycol chitosan (GC), poly-L-lysine and polyethyleneimine to allow uniform dispersion (...
[33,43,44,45]. A chitosan-agarose polysaccharide-based hydrogel has been fabricated, which can form biomimetic growth layer without any gaps [46]. The Ca/P value of the hydrogel is close to that of the native enamel and has the formation of enamel-like hierarchical structured layers under....
While medical student distress in the form of anxiety, depression, and burnout has been well documented in the literature, [9,10,11,12,13,14] there is a scarcity of studies examining the impact of curriculum on mental health. The traditional, lecture-based learning (LBL) curriculum has long...