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What makes the show even more interesting is that the contestants are completely stripped of technology, meaning they can't check their phones or laptops like in everyday life. They have to interact with each other wholeheartedly and try to form connections with each other by communicating and...
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In the statistical learning literature, the use of prior information (e.g., biological information in the form of variable–variable interactions) in variable selection methods has the potential to identify correlated variables with greater ability to produce interpretable results and improve prediction ...
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Protein drugs are of great importance in maintaining the normal functioning of living organisms. Indeed, they have been instrumental in combating tumors and genetic diseases for decades. Among these pharmaceutical agents, those that target intracellular
DNA methylation referring to the methylation of cytosines in the context of d (CG) dinucleotides, is a prominent form of epigenetic modification. DNA methylation plays an essential role in regulating the expression of mammalian oncogene and tumor suppressor genes [6] and participating in the develop...
Generalizing the functional form of epistasis If epistasis is taken in its statistical sense as the deviation from the additive/linear baseline, then all other terms—namely quadratic and higher order interactions—are epistasis [9]. The relation between genotype and phenotype can then be represented...
Then, we selected the genes that showed a significant association with prognosis of patients. And the glmnet package in R was used to perform LASSO multivariate Cox regression algorithm with 1000 cross-validations, enabling us to identify a robust prognostic model from the selected genes. The ...
Lastly, the tanh transformation applies the hyperbolic tangent function to scale the data to a unit range while decreasing the influence of extreme values [16]). Feature selection methods Four well-performing feature selection methods were employed [17]: LASSO [18], extra trees (ET) [19], ...