acquired Angola’s petroleum to meet China’s high domestic energy demands. Angola has repaid the majority of its debt to China in the form of extracted oil. This contractual arrangement is known as the “Angolan model.” However, China’s large loans only enriched a small segment of Angola...
Domain A, located at the N-terminus of GSDME, is predicted to have an alpha/beta fold, whereas domain B, located at the C-terminus of GSDME, is predicted to have long alpha-helical structures that may form coiled-coils. In breast cancer tissues, Thompson and Weigel (1998) found that ...
Key discoveries and innovations in the field of human genetics have led to the foundation of molecular and personalized medicine. Here, we present the Genome Tunisia Project, a two-phased initiative (2022–2035) which aims to deliver the reference sequen
Histone modification H3K27me3 plays a critical role in normal development and is associated with various diseases, including cancer. This modification forms large chromatin domains, known as Large Organized Chromatin Lysine Domains (LOCKs), which span se
CME-associated clathrin–coated vesicles entering cells form early endosomes and receive endocytic material through the endosomes to complete sorting [53]. A portion of the cargo proteins are used to recycle the PM. Another fraction of the cargo proteins is processed and ubiquitinated, eventually ...
(Bordalo et al.2015), corporate cash holdings (Dessaint and Matray2017), investor skewness preference (Dertwinkel-Kalt and Koster2020), asset allocation (Alok et al.2020), stock trading models (Huang et al.2018; Frydman and Wang2020; Sim and Kim2022), and mutual fund flows (Hu et al....
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence rates and severity of progression. The cellular and molecular mechanisms underlying this clinical phenomenon remain elusive and ill-defined. ...
s high-quality revenue stream and critical mission properties. we also believe that the experienced management team provides alpha in the form of deep-rooted relationships that will drive expansion in the years ahead. this idea was discussed in more depth with members of my private investing ...
Metastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization and is determined by tumor-stroma interactions, yet the mechanistic underpinnings remain incompletely understood. PCR
Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments is required to elucidate mechanisms of tum