CD55 deficiency with hyper-activation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) disease is ultra-rare (< 100 children or young adults worldwide) and potentially fatal. The study used mixed-methods approaches to
A predominance of CD4 + and Th2 cells with infiltration of eosinophils and mast cells in the airways characterises type 2 airway inflammation. CD4 + and T helper cells initiate and perpetuate the phenotype of prolonged inflammation [39]. This type of inflammation primarily drives allergic...
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mRNA expression, miRNA expression, copy number variation, DNA methylation, etc.) from the same samples. The objective of these experiments is usually to find a reduced set of significant features, which can be used to differentiate the conditions assayed. In terms of development of novel ...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
Our main interest lies in (sub-)networks comprised of nodes that form a module inside a larger network. Since a particular module network may encode a pathway or a protein complex, these special types of networks have great practical importance. Similar to the term 'cluster', no consensus on...
of CFD solvers. Regarding the grid skewness, there are various definitions of that, such as the angle between face normal and the vector pointing form face centroid to the cell centroid, the minimal internal angle of grid cell [25], ratio of the max diagonal to the minimum [26], etc. ...
We use HMMs to represent the chromatin states as hidden states and all possible combinations of (binarized) epigenetic marks as observations. The whole genome is divided into segments of size 200 bp following [15,62]. We define the HMM in matrix form as follows. Note the matrix and vector ...
We connect the nodes in the two similarity networks in the form of weighted directed edges as follows: The m nearest neighbors of Cx(1) in similarity network S1 is {Cx1(1),Cx2(1),…,Cxm(1)}. The mirror nodes of this m nodes in similarity network S2 is {Cx1(2),Cx2(2),…,Cxm...
ACE metabolizes angiotensin (Ang) I to form Ang II, which is of key importance in the pathophysiology of the RAS in the heart [2]. Recently, ACE2, a new member of the RAS, was found to function as a negative regulator of the Ang system by metabolizing Ang II to a putatively ...