Compared to those tissue stem cells existing in adult tissues or organs, embryonic stem cells (ESCs) derived from the inner cell mass of blastocysts are pluripotent which can form three germ layers (ectoderm, mesoderm, and endoderm) (Thomson et al., 1998). In addition to ESCs, human-induced...
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Furthermore, sufficient energy in the form of ATP must be generated to enable the fermenting organisms to grow and remain viable. However, this yield obtained from a simple stoichiometric balance indicates that a high-yielding photochemical or electro-chemical route to PDO may be possible in the ...
The biological effects observed in the aforementioned PDNVs form the basis for their tissue protection and repair properties. However, some studies have only conducted a superficial assessment of the PDNVs' activity without delving into the specific underlying mechanisms. It remains unknown whether the...
In biodesulfurization (BD) at haloalkaline and dO2-limited conditions, sulfide-oxidizing bacteria (SOB) effectively convert sulfide into elemental sulfur t
To further construct focused subgraphs from the GBPN for supporting high-influence node identification for drug repurposing or repositioning, we derived modularity class-based subnetworks (mc_GBPN) by leveraging community detection, a form of graph clustering algorithm. Through implementing multiple ...
For example, in breast cancer tissue: (1) the “sulfatase pathway” and “aromatase pathway” are upregulated, thereby providing a steady stream of precursors for estrogen synthesis in the form of inactive steroid sulfates or androgens, respectively, and (2) the reductive 17-β-hydroxysteroid ...
We combined the original data from 19 blood samples (HY and LH) with 36 database resequencing data (ZE, ZD, SC, and ST) to form the 55 samples (Table 1) in the study. Based on the sequencing results, the average sequencing depth reached 11.75X, with the min and max being 8.07X an...
The aggregation of the “sticky” form, amyloid-β42, into fibrillar structures has been established as one of the mechanisms leading to all known clinical symptoms of Alzheimer’s disease. Consequently, we decided to investigate the role of PSEN1 in neuronal cell death in AD. NeuroDNet tool ...
e Visualization of TLS-like domain detection of SpaDo and other methods (BayesSpace, SEDR, SpaGCN, Scanpy, and Seurat v4) on 4 RCC spatial transcriptomic datasets Full size image The spatial domains detected by SpaDo form a multi-resolution schema hierarchically, enabling the characterization of...