e Visualization of TLS-like domain detection of SpaDo and other methods (BayesSpace, SEDR, SpaGCN, Scanpy, and Seurat v4) on 4 RCC spatial transcriptomic datasets Full size image The spatial domains detected by SpaDo form a multi-resolution schema hierarchically, enabling the characterization of...
Given the broadening interest in long-read sequencing and the fast-paced development of applications and tools, the current review aims to provide a description of the guiding principles of long-read data analysis, a survey of the available tools for different tasks as well as a discussion of t...
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Photosynthetic microalgae require polar polyunsaturated lipids in particular for membrane where fluidity is critical, while most storage lipid occurs in the form of lipid bodies containing triacylglycerides. These typically vary in their composition and typically contain a mixture of saturated and ...
Oral infection with cysts is the main transmission route of Toxoplasma gondii (T. gondii), which leads to lethal intestinal inflammation. It has been widely recognized that T. gondii infection alters the composition and metabolism of the gut microbiota,
suggests they may form from near-surface chloride and sulfate salt brines [14]. Geomorphological features resembling gullies formed in the recent geologic past [15] are suggested to have formed from subsurface eutectic brines [16]. Thus, the GH springs provide a useful analog for examining ...
Systematic in vitro loss-of-function screens provide valuable resources that can facilitate the discovery of drugs targeting cancer vulnerabilities. Results We develop a deep learning-based method to predict tumor-specific vulnerabilities in patient samples by leveraging a wealth of in vitro screening dat...
The biological effects observed in the aforementioned PDNVs form the basis for their tissue protection and repair properties. However, some studies have only conducted a superficial assessment of the PDNVs' activity without delving into the specific underlying mechanisms. It remains unknown whether the...
Cattle were deprived of water during transportation, while they could eat some wheat straw, which was placed on the sides of the cart in the form of straw bundles when loading. Before transport, the ratio of concentrate and wheat straw in diet was 30:70. The concentrate was purchased from ...
The androgen receptor (AR) is a member of the nuclear receptor (NR) superfamily of ligand-inducible DNA transcription factors, and is the major mediator of male sexual development, prostate growth and the pathogenesis of prostate cancer. Cell and gene specific regulation by the AR is determined ...