The radioimmunoassay for insulin required an overnight, equilibrium incubation and used a unique antibody that has less than 0.2% cross-reactivity to human proinsulin and its primary circulating split form Des 31,32 proinsulin (Linco Research, St Louis, Mo). Blind analysis of split serum samples ...
The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting tech
Ferroptosis is a form of cell death caused by iron-dependent lipid peroxidation and ROS accumulation characterized by the reduction or loss of mitochondrial cristae and rupture of the outer mitochondrial and mitochondrial membranes condensation [72]. Zhang et al. [73] found that transferrin ...
Oocyte aging is a key constraint on oocyte quality, leading to fertilization failure and abnormal embryonic development. In addition, it is likely to generate unfavorable assisted reproductive technology (ART) outcomes. SCM-198, a synthetic form of leonu
Another molecular biomarker of glioma subtypes is the methylated form of O6-methylguanine-DNA methyltransferase (MGMT) promoter, which has prognostic, predictive and clinical applications [48]. MGMT promoter methylation serves as a prognostic and predictive marker in GBM diagnosis, predicting the response...
Examining the mechanistic cellular responses to heat stress could aid in addressing the increasing prevalence of decreased fertility due to elevated ambient temperatures. Here, we aimed to study the differential responses of oocytes and granulosa cells t
(81), the mouse mast cell protease (mMCP)-6 [62], and function as growth suppressor in fibroblasts [63]. SAF-1 transgenic mice are prone to develop a severe form of inflammation-induced arthritis [64]. MAZ is upstream of Aplp2 which is a key regulator of structure and function of ...
Astrocytes are known to be a source of pro-inflammatory cytokines [8] and in the advanced stages of injury progression form a glial scar inhibitory to neural regeneration [9]. However, reactive astrocytes generally serve a protective role during the early stages of injury and are responsible for...
Two connexons from adjacent cells dock to form a GJ channel. In mammals, numerous studies indicate that ovarian GJ communication is involved in regulation of the meiotic arrest of oocytes, steroidogenesis, and apoptosis [6–9]. In fishes, by contrast, detailed information on the distribution, ...
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