Acrylamide and N,N鈥 -methylenebisacrylamide were copolymerized in the presence of a protein to form a gel which was pressed through a sieve. The gel partic... JL Liao,Y Wang,S Hjertén - 《Chromatographia》 被引量: 234发表: 1996年 Quantitation of HLA Class II Protein Incorporated into ...
Fusobacterium is a common oral bacteria that form biofilms on teeth and epithelial tissues [29]. Fusobacteria-dominant polymicrobial biofilms have been detected in RCC to contain Bacteroidetes, Lachnospiraceae, and Enterobacteriaceae [14, 15]. Moreover, F. nucleatum is a type of oncogenic bacteria ...
Mechanisms of ferroptosis Ferroptosis was first proposed by Dixon and his colleagues in 2012 and is a different form of regulated cell death (RCD). It was defined as iron-dependent lipid peroxidation [1]. Figure 1 Iron is an essential trace element in the organism with a variety of physiologi...
PR exists in two isoforms: a smaller isoform, a 94 kDa protein (form A) and a bigger isoform a 120 kDa protein (form B), due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is also involved in extra nuclear signaling activation. PR-...
2023). This particular form of breast cancer is widely regarded as one of the most hostile. Due to the insufficient expression of ER, PR and HER2 in TNBC tumors, patients derive limited benefit from existing endocrine and targeted therapies (Derakhshan and Reis-Filho 2022). As a result, ...
Integrins, comprised of α and β subunits non-covalently bound together, form heterodimeric complexes found in endothelial cells, pericytes, fibroblasts, and tumor cells. In mammals, there are a total of 18 α subunits and 8 β subunits. Through their mutual combinations, at least 24 αβ inte...
In addition to the high immune heterogeneity of tumor cells, the heterogeneity of other cell types further increases the complexity of tumor tissue. These different types of cells form a complex interaction network through ligand-receptor interaction, paracrine, autocrine, and other intercellular ...
The incidence of brain metastases (BrM) in patients with metastatic melanoma is reported to be 30–50% and constitutes the third most frequent BrM after breast and renal cancers. Treatment strategies including surgical resection, stereotactic radiation, and immunotherapy have improved clinical response ...
This signature serves as a valuable reference for further exploring the role of tryptophan metabolism in renal cell carcinoma and for the development of clinical applications based on this metabolic pathway.Introduction Renal cell carcinoma (RCC) is the most prevalent form of kidney cancer, ranking ...
TGF-β and IL-10 secreted from TAMs are important factors that form the microenvironment of immunosuppressive tumors [30]. PD-L1 on cancer cells engages with PD-1 on immune cells, contributing to cancer immune escape [31]. Additionally, TAMs are known to be instrumental in the ...