The biogenesis of of miRNAs is initiated in the nucleus where the introns of protein-coding genes or independent genes are initially transcribed by RNA polymerase II/III to form primary miRNA transcripts (pri-miRNA) [70,71]. The RNase III protein Drosha then processes the pri-miRNA with its ...
2020). Whether consumed in whole form, as part of a salad, or in mixes (smoothies), fruit and vegetable intake is critical for a well-balanced diet. Smoothies are a type of semi-liquid product primarily based on fruit and/or vegetable and possesses a smooth consistency and nutritional ...
The ethical review committee of Peking University approved the CLHLS study and the participant or their representatives signed the informed consent form (IRB00001052-13074). Competing interest The authors declare no competing interests.Additional information Publisher’s Note Springer Nature remains neutral...
This decision can be made if termination is in the best medical interest of the patient. An end-of-study case report form will be completed to document the final termination in the study. The infusion rate and duration will generally not be subject to modification. However, if a suspected ...
of the biliary tree possess distinct functions, adapting to varying microenvironments. Subsequently, cells from IHD, CBD, and GB were cultured under specific conditions to form organoids, and scRNAseq analysis was conducted on these cholangiocyte organoids [50,51]. According to UMAP and Principal...
In this study, death before the age of 70 years was defined as premature death—the outcome variable. All study participants were followed up annually by telephone and with a follow-up form, which included 40 items, such as vital signs, hospitalizations, deaths, and the occurrence of new ...
When autophagosomes fuse with lysosomes to form autolysosomes, GFP is quenched because of the acidic environment inside lysosomes, indicating the smooth formation of autolysosomes. At the same time, mRFP is always stably expressed, so the process of autophagy flow is evaluated by the ratio of ...
The full protocol and informed consent form were approved by the Institutional Review Board of Sun Yat-sen University. All participants provided written consent before study entry. Consent for publication Not applicable. Competing interests The authors declare no competing interests....
Ferroptosis is an iron-dependent form of regulated cell death that has become increasingly recognized as an important process mediating the pathogenesis and progression of numerous cardiovascular diseases, including coronary atherosclerosis, heart failure, arrhythmia and diabetic cardiomyopathy [33]. Increased...
First, where the order of years was backwards on the RHM form, we assumed this occurred because of a genuine error and reversed the order accordingly. Second, where respondents’ age indicated that a reported address was inhabited before their birth, we adjusted the entries as follows: If the...