IL-12p70, the active heterodimer form of IL-12, is a potent proinflammatory cytokine that is known to potentiate T and NK cell cytotoxicity in the tumor microenvironment [46]. Interestingly, there were no cytokines significantly correlated with tumor burden in the 4T1 cohort. We then performed...
During the past two years, the COVID-19 pandemic has cost millions of lives around the globe, caused major morbidity and provoked widespread economic and social disruption. In response, governments have enacted policies to mitigate the impacts of the pan
Preflight Checklist I agree to follow the Code of Conduct that this project adheres to. I have searched the issue tracker for a feature request that matches the one I want to file, without success. Describe the bug 'Viewer does not suppo...
private_key=**redacted**>>># Return an encrypted instance>>>encrypted=address.encrypt('foo')>>>printencrypted<EncryptedAddressprivate_key=6PYN7vxDNYgNn7cBVfB8KErNWWBKTKFRA9yB9DoQnukhX1iJzj6mkPgHvj>>># Decrypt with an incorrect password>>>printencrypted.decrypt('bar')None>>>printencrypted.dec...
Silva CL, Bonato VL, Coelho-Castelo AA, De Souza AO, Santos SA, Lima KM, Faccioli LH, Rodrigues JM: Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice. Gene Ther. 2005, 12 (3...
Apoptosis has historically been believed to be the only form of programmed cell death (PCD), and necrosis, which was believed to be an “accidental” type of death not regulated by molecular events [3], was assumed to be the diametrically opposite modality of cell death compared to apoptosis...
Therefore, in contrast with the affinity of BPTI to trypsin, many sea anemone Kunitz-type inhibitors such as InhVJ, Jn-IV, and APHC1–APHC3 display a (Figure 1b) significantly lower potency (in the range of Ki values 10−6–10−9 M). As such, the trypsin inhibitory activity is ...
Assembly and release of viruses constitute the last step of viral replication, where the mature virus particles are released from host cells in the form of exocytosis and budding. So far, there have been few reports of TCM acting on this stage. Virus envelope (E), membrane (M), nucleocapsid...
Such data provide a rich source of information on key implementation considerations. Consent was sought from those involved in meetings to use anonymised high-level meeting notes as a form of data. In any cases where consent was not granted, individual contributions were redacted from the notes ...
Kanaeda and colleagues have previously demonstrated that inactivated Sendai virus (also known as hemagglutinating virus of Japan envelope, or HVJ-E) stimulates anti-tumor immunity in renal and...doi:10.1038/NRUROL.2009.114Sarah Payton