In this study, two reviewers (MS and TE) independently extracted data from the included studies using the data extraction form prepared by the research team based on the objectives of the study. This form was developed in Covidence (Additional file 4). To enhance the clarity, relevance, accura...
–Insulin resistance is also believed to be linked to a form of systemic inflammation. The key cause of the inflammation (triggered by the immune system) are fat cells. In type 2 diabetes, the immune system releases inflammatory mediators called cytokines against fat cells. Unfortunately, those c...
In living tissue, cells synthesize ECM components and deposit them to form a niche. A niche not only affects the tissue composition and mechanical properties, but also determines cellular fate. As aforementioned that islet β-cell can rarely proliferate in vitro. Thus, many attempts have been ...
Wuli, there, yonder; (out of use; at present nellak, A.) Wuliachpin, to be in a good place. Wuliechen, it is good, it is well done. Wuliechenummen, to take down; (this means to split into splinters; the proper form wuniechenummen. A.) Wuliechsin, to speak plainly, ...
The case report form is viewable as Additional file 1. We pre-defined factors thought likely to be associated with ICU-AI, namely age, sex, aggregate comorbidity score, use and duration of corticosteroids, need for invasive mechanical ventilation, vasopressors and renal replacement therapy, duration...
(SSNs) that represent sequences as nodes and their pairwise similarity as weighted edges are a more flexible concept to model subtle sequence relationships that may interlink sequence clusters [6]. It follows that the set of GNs deduced for all nodes of an SSN also form networks, commonly ...
HELLP syndrome is a life-threatening form of preeclampsia characterized by hemolysis, elevated liver enzymes, and low platelets and may occur without hypertension or proteinuria. Preeclampsia can be divided into two subtypes: early-onset (or placental) and late-onset (or maternal) preeclampsia [5]....
For endosomes, Meth exposure upregulated Rab5 expression and its guanine-nucleotide exchange factor (GEF) (immature endosome), with a commensurate decreased active form of Rab7 (Rab7-GTP) and impeded the binding of Rab7 to CCZ1 (mature endosome); for autophagosomes, Meth treatment elicited a ...
Among these fractions, PCP-EF showed the best effect in the increase of the conversion of the cytosolic form of LC3 (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II) and the average number of GFP-LC3 puncta per cell (Additional file 1: Fig. S2C, D). Taken together, the ...
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