Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas, oligodendrogliomas, glioblastoma multiforme (GBM), and mixed t...
H3K27M-mutant DMG and H3G34R-mutant HGG are both driven by oncohistones but arise in discrete brain regions (forebrain and hindbrain, respectively). To investigate the underlying mechanism, Bressan et al. and Funato et al. independently compared the oncogenic effects of H3K27M and H3G34R ...
Hypomethylation levels of Alu are associated with high fasting blood sugar, HbA1c and blood pressure in leukocytes of T2D patients [45]. In addition, CBX7 is a component of Polycomb group (PcG) of proteins, which form Polycomb Repressive complexes (PRCs) to regulate gene expression through hist...
Subtle deviations in heart development can result in congenital heart disease (CHD), which is a collection of defects that together comprise the most prevalent form of birth defect with a birth prevalence of 0.8% of all newborns [2, 3]. The etiology of CHD is incompletely understood and ...
All 350 patients were diagnosed with HGG (WHO grade III–IV), and the pathological types, including glioblastoma and AA. Two prospective studies associated with carbon-ion therapy were undertaken in Japan and China, while the rest of the research was conducted in two countries (USA, Germany)....
[15,33]. Additionally, it has been demonstrated that the G1405 position on the bacterial 16s RNA is selectively methylated to form the m7G modification, which results in resistance to aminoglycosides [34]. However, the role of m7G modification in rRNA is not fully understood and further ...
Conclusions Altogether, our findings highlight the functional role of MELK as a promising target in molecular therapy and in the combination of RT therapy to improve antitumor effect for HCC.Background Hepatocellular carcinoma (HCC), the most prevalent form of primary liver cancer, ranked as the ...
Phase 0/1 “window of opportunity” clinical trial of BDTX-1535 began enrollment in October 2023 to evaluate the pharmacokinetic, pharmacodynamic, and clinical response in patients with recurrent high-grade glioma (HGG) with EGFR alterations and/or fusions who are undergoing a planned surgical resect...
Regarding xib2, our analysis revealed an intriguing bifurcation. While one form of xib2clusters with other arthropod ICKs, its isolated positioning casts doubt on the significance of these associations. Interestingly, that sequence is the transitional xib2sequence with only eight cysteines, which could...
High-grade gliomas (HGGs), which include grade III anaplastic astrocytomas and grade IV glioblastomas (GBMs), the deadliest form of brain tumor, are notoriously heterogeneous at the cellular level [1,2,3,4,5]. While it is well-established that transformed cells in HGG resemble glia [6, ...