Acute lung injury (ALI) is a complex disease with numerous causes. This review begins with a discussion of disease development from direct or indirect pulmonary insults, as well as varied pathogenesis. The heterogeneous nature of ALI is then elaborated u
However, the available mouse gastric cancer cell line commonly used for modeling in immunocompetent mice is limited to the mouse forestomach carcinoma (MFC) cell line, which originates from squamous cell carcinoma of the mouse forestomach—a region not present in humans—thus lacking clinical ...
In the human GI tract, the production of acid and enzymes by the gastric mucosa can influence properties of ingested nanomaterials. The gastric phase for food digestion may last 3–4 hours. During this time, ingested materials are processed by acids and enzymes, and the pH in the stomach ...
Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM Xiaocong Li, Shipeng Zhang, Huafang Sheng, Yan Zhen, Buling Wu, Zhuang Li, show all Article: 2453964 | Received 23 Apr 2024, Accepted...
In pharmaceuticals, L-Citrulline can serve as a precursor for developing therapies targeting cardiovascular diseases or enhancing nitric oxide production [4,5,6]. Citrullination pathways, employed in the production of L-form amino acids, are essential for synthesis of various antibiotics. In food ...
Infestation by tea green leafhoppers (Empoasca (Matsumurasca) onukii) can cause a series of biochemical changes in tea leaves. As a typical cell-rupture feeder, E. onukii secretes proteases while using its stylet to probe the tender shoots of tea plants
We observed a more isolated clustering of epithelial and stromal cells compared with immune cells, which have circulating capability. Because epithelial and stromal cells are fundamental components that form protective barriers and supporting matrix for many organs, disruptions in their homeostasis have bee...
Beneficial effects of dietary phospholipids (PLs) have been mentioned since the early 1900's in relation to different illnesses and symptoms, e.g. coronary heart disease, inflammation or cancer. This article gives a summary of the most common therapeutic
TGF-β as a proto-oncogene is important in stromal-epithelial cross-talk, as was shown for the first time in mouse experiments, where deletion of the TβRII in stromal fibroblasts resulted in transformation of adjacent epithelia of prostate and forestomach. Moreover, in this model, hepatocyte ...
ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. To help determine the function of ERK5 we have used gene targeting to inactivat