All cases were received in the form of multiple pieces ranging from 1.0 cm to 11 cm in aggregate. Mean and median size was 4.6 cm and 4 cm, respectively. On histological examination, all cases demonstrated a multinodular growth pattern (Fig. 2A, B), and the specific glioneuronal element...
Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. However, the microglial het
Non-alcoholic steatohepatitis (NASH) is a liver disease currently lacking an approved therapy, resulting in significant clinical demand. Traditional Chinese medicines (TCMs) have been commonly used to manage NASH. This study aimed to systematically analy
We observed the highest P/LP burden in genes related to severe/recessive lethal conditions, ciliary disorders, hearing loss, and congenital structural anomalies, with 5 genes harboring more than 1 P/LP variants per gene adjusted for gene length: HBB, TMEM107, GJB2, HBA2, and HBA1) (Fig....
The lack of effective understanding of the pain mechanism of McCune–Albright syndrome (MAS) has made the treatment of pain in this disease a difficult clinical challenge, and new therapeutic targets are urgently needed to address this dilemma. This pape
Around the UB tips, nephron progenitor cells (NPCs) polymerize to form the cap mesenchyme (CM) and further differentiate into pretubular aggregate (PTA), renal vesicle (RV), s-shaped body (SSB), podocyte, proximal tubules, and loops of Henle through sophisticated mesenchymal–epithelial ...
Its precise location will be written down in the Investigator Site File. The patient data will be recorded in a case record form in CASTOR. Plans for collection, laboratory evaluation, and storage of biological specimens for genetic or molecular analysis in this trial/future use {33} Not ...
With these multiple collaborations based on the assets generated from HBICE®, Harbour Therapeutics has shown its strength and unique advantages in building a comprehensive portfolio in immune cell engagers. And the co-development and collaboration of the pipeline is not only the recognition of the...
making them valuable in preventing and treating respiratory conditions. Ferroptosis, a unique form of programmed cell death (PCD) distinct from apoptosis, necrosis, and others, has emerged as a key area of interest. However, comprehensive reviews on how natural products influence ferroptosis in respir...
The right of a participant to refuse to participate in this trial without giving reasons for the decision will be respected. Additional consent provisions for collection and use of participant data and biological specimens The consent form received from the patients includes their agreement to use...