2011). Together, the T2 and T3 copper sites form a trinuclear center (T2/T3) with 12 Å away from T1 (Alcalde 2007; Hakulinen and Rouvinen 2015). In addition, water results from the reduction of molecular oxygen ending the catalytic cycle of the enzyme (Alcalde 2007; Arregui et al....
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YC and YPW carried out the experiment, analyzed the data, and drafted the manuscript; FNG, LL, YQW, HL and MD carried out the phenotypic evaluation; YZZ, ZEP, WL, QTJ, JRW, YMW, JM, QX, HYK, PFQ, ZWY, LQZ, DCL and YLZ provided resources and technique guidance; YFJ and GYC desi...
NPIs will therefore not be included in our analysis, even though they form an integral part of the crisis response arsenal. Three main types of MCMs against viral emerging agents should be considered: antivirals (small chemical molecules), monoclonal antibodies (mAbs), and vaccines. The analysis...
However, there is genetic evidence that the β-subunit like sGC proteins GCY-35 and GCY-36 of C. elegans can function as α/β-like heterodimers [54]. Thus the initial form of the eukaryote O2 sensitive sGC may have been a homodimer, with subsequent evolution and diversification of the ...
This was found to be a copper type-2-depleted form in which the putative T2 copper is completely absent and therefore is in a catalytically incompetent state. The difficulties in successfully crystallizing the active form of laccase have been unanimously attributed to the occurrence of extensive ...
GYC, XJZ, and SC, the lead study coordinators, comprise the trial steering committee. Additionally, three independent members from the Clinical Trials Office of Sir Run Run Shaw Hospital, along with the three lead coordinators, will serve as the coordinating center for this study. These committees...
For genes arranged in tandem on the same strand and not predicted to be part of an operon by JPOP, we considered them to form an operon if their intergenic distances are shorter than 45 base pairs. Genes that were not covered by this procedure were considered to each form a singleton ...
In the last two decades it has furthermore been recognised that 5' untranslated regions (5’UTRs) frequently form secondary structures that can inhibit or promote translation of the downstream open reading frames (ORF). Moreover, they can form simple hairpin structures that block 5' ...