as the lake harbors hundreds of colorful fish species (Figs.1A and2E). Lake Malawi is part of a chain of lakes in the East African rift, an active continental rift zone that started to form 20–25 million years ago [1]. The rift gave...
affordable fossil fuels will eventually run out, compelling a shift to renewables [62,63]. This is why advancing renewable technologies is now important. Unlike fossil fuels, which take millions of years to form, at present usage rates, the fossil fuel era will last only approximately 400 ...
Most of the SNPs related to vitamin B12 status have been examined using a candidate gene approach [8]. However, it is now possible to use an unbiased genome-wide association (GWA) study to associate DNA sequence variations across the human genome with the risk factors of developing a disease...
Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common polygenic forms; research into the genes involved in both types has provided insights into the many contribut
In addition, many of the key ethical challenges of GWA studies have only been identified fairly recently. Pertinent issues like consent and privacy remain the topic of debate [43], and consensus about the best approach to accommodate these challenges in research has not been reached. It is ...
Over the last few years, genome-wide association (GWA) studies became a tool of choice for the identification of loci associated with complex traits. Currently, imputed single nucleotide polymorphisms (SNP) data are frequently used in GWA analyzes. Correct analysis of imputed data calls for the ...
Comparison of different GWA models. Cumulative distribution of P-values computed from 918 SNPs and row-type phenotype for different association models are presented. The more uniform the distribution of P-values, the better is the model Full size image Barley spike morphology (row type) Apart from...
A room impulse response (RIR) characterizes the linear time-invariant acoustic propagation between a source and a receiver within a specific acoustic environment. RIRs are crucial for sound field auralization [1] as well as in the realm of room acoustics, where they are used for estimating acoust...
In GA, a population is a set ofnindividuals that form potential solutions. For workload estimation, we define each individual/chromosome as a set of decimal values. Each chromosome is an estimated workload value for the current workload attribute of the workload profile under evaluation. For in...
Usually such treatments, in the form of oral steroids, are reserved for exacerbations of the disease, but if there is an autoimmune component, oral steroids and other immunosuppressants might be effective at other times as well. New treatments for COPD Phosphodiesterase 4 (PDE4) inhibitors are ...