An increasing body of research substantiates the significant connection between the gut microbiota and distant organs(Fig.1).Gram-negative bacteriaor LPS in the gut accelerate the formation of cerebral cavernous malformations (CCMs) through the TLR4 pathway, a phenomenon that is not observed in germ...
To understand whether the fishbone could usefully summarize comparative treatments that might form the basis of a clinical practice guideline, we took the findings from a systematic review of randomized controlled trials (RCTs) of preoperative anemia management versus usual care (“anemia fishbone”,...
Gait-lines, or the co-ordinates of the progression of the point of application of the vertical ground reaction force, are a commonly reported parameter in most in-sole measuring systems. However, little is known about what is considered a "normal" or "abnormal" gait-line pattern or level ...
cDNA microarrays measure the amount of messenger RNA (mRNA) contained in an experimental sample. They are produced by robotic arrayers, which place entire gene sequences complementary to mRNA onto glass slides. In an experiment, the mRNA in two samples, e.g. treated and control, are fluorescen...
Gold in a bulk form has been observed to be a poor catalyst. But gold in the form of nanoparticles shows excellent catalytic activity towards the deoxygenation of epoxides into alkenes and reduction of ferrocyanate (III) and nitroarenes (Reddy et al. 2015a; Ju and Parales 2010). The 4-...
There are two isoforms of 11β-Hydroxysteroid dehydrogenase. 11β-HSD1 which converts the inactive 11β-keto form (cortisone in humans and 11-dehydrocorticosterone in rodents) to the active 11β-hydroxylated GCs (cortisol in human and corticosterone in mice) [3]. It is expressed primarily in...
Chronic Obstructive Pulmonary Disease (COPD) is a growing worldwide problem that imposes a great burden on the daily life of patients. Since there is no cure, the goal of treating COPD is to maintain or improve quality of life. We have developed a new tool, the Assessment of Burden of CO...
The current challenge of Systems Biology is to integrate high throughput data sets for simulating the complexity of biological networks, exploit the evolution of nature-designed networks that maintain the robustness of a biological system, and thereby ge
Gait-lines, or the co-ordinates of the progression of the point of application of the vertical ground reaction force, are a commonly reported parameter in most in-sole measuring systems. However, little is known about what is considered a "normal" or "abnormal" gait-line pattern or level ...