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Dysfunctional iron metabolism has been linked to elevated iron levels and ferroptosis, a form of cell death. Studies further suggest a connection between ferroptosis and various kidney diseases: targeted iron-induced cell death may provide therapeutic benefit in acute or chronic kidney injury, diabetic...
Briefly, the neuroectodermal in the form of neuronal rosette were generated from multipotent iPSC aggregates (EBs) in suspension using minimalistic media, coupled with Matrigel embedding, and followed by the expansion of the elaborate architecture of the germinal zone of neural stem cells or ...
The sporadic CRCs, with no family history or genetic predispositions, account for approximately 65% of total CRCs diagnosed worldwide [2], whereas inherited types of CRCs constitute the remaining 35% [3, 4]. CRC development may take decades to transform into the final form of cancer. Many ...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
Increasing the endogenous IAA content induces cell differentiation to form ARs [18], and anything that affects IAA synthesis and transport can alter the development of the lateral roots [19, 20]. The crosstalk between ethylene and IAA in regulating root formation shows that the AR formation ...
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report that de-glycosylated clusterin shows a propensity to form higher oligomers than wild-type glycosylated secreted clusterin40. In our studies, we noticed that both α-Clu and β-Clu form higher order oligomers with large hydrodynamic radii and large molecular weights as observed in sedimentation...
In 2009, the Muir group reported an intein selection system using the kanamycin resistance gene. TheirkanR-Npuselection plasmid includesNsil andNcol sites, which were inserted into thekanRgene through silent mutation. Intein cloning generates a split form ofN-kanRandC-kanR. We obtained this plasmid...
The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β (gp130) on the cell membrane. A recombinant soluble form of the IL-11Rα (sIL-11Rα) in combination with IL-11 acts as an agonist on cells expressing ...