Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultrav
Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancers during the previous ten years. However, its effectiveness in treating solid tumors is still lacking, necessitating the exploration
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates...
The research involving clinical samples was approved by the Ethics Committee of the China-Japan Union Hospital of Jilin University (Date 7.3.2023/No.2023070309), and each patient has signed a written informed permission form. The animal experiment was approved by the Ethics Committee of the First...
invasiveness, it can also stimulate anti-tumor immune responses that inhibit tumor progression [40,41]. Recent research has highlighted the potential of therapeutic strategies aimed at inducing pyroptosis within tumor cells. By triggering this form of cell death, it is possible to activate the ...
Full-length GSDM molecules cannot induce apoptosis. Active caspases shear and release their cytotoxic N-terminal domains, which can polymerize on the cell membrane to form pores and trigger pyroptosis [13, 19, 24]. As a suppressor of tumor growth, GSDME primarily inhibits tumors by facilitating ...
[7]. The emitted electromagnetic energy is considered as reflected light, which forms certain characteristic spectral signatures depending on the sensed object and its state. The advantage of HSI-systems compared to non-imaging systems is the acquisition of spatial information in the form of pixels....
(GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates nuclear ...
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis mediated by full-length (FL) GSDME without proteolytic cleavage. Intense ultraviolet-C irradiation-triggered DNA damage activates...
In this paper we focused on key metrics of real-world walking that form the basis from which a variety of digital mobility outcomes, including walking speed, can then be quantified. These are: gait sequence detection, foot initial contact detection, cadence and stride length estimation. For each...