Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology in healthcare while addressing the critical aspects of safety...
The simplest Poisson model of the form (3) is one in which θij is the same across all cells i, that is, θij=pj0 for all i=1,…,n. We treat this a “null” model, which can be used to make certain comparisons, e.g., to estimate changes in expression in relative to express...
Inflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a role in both diseases. Exploring the genetic basis of the I
Type 1 diabetes (T1D) is a metabolic disorder caused by the autoimmune destruction of beta cells in the pancreatic islets of Langerhans, resulting in hyperglycemia [1]. As of 2021, there were an estimated 537 million people worldwide living with some form of diabetes, with T1D accounting for...
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients wh...
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for cancer therapy. Ho
While normal cells cocluster with healthy cells, tumor cells with distinct transcription features form isolated clusters [14, 19, 20]. This alternative strategy has been widely adopted, as high-throughput 10X Genomics scRNA-seq has constrained mutation detection due to 5’- or 3’-biased ...
[60]. For IVT-produced circRNAs, half self-spicing introns have been incorporated into a construct in order to induce splicing of an exon-linked target gene into a circular form; expression was driven by an internal ribosome entry site (IRES) in front of the target gene. Alternatively, ...
In recent years, the field of malignant tumor biology has yielded a multitude of effective anticancer drugs. However, the inherent heterogeneity of tumors and the development of drug resistance often render single-drug therapies targeting individual markers ineffective [1]. In contrast, drug combination...
of molecular biology and immunology and is at the forefront of gene therapy (Table1). In these vaccines, exogenous antigens encoded by mRNA are introduced into somatic cells, promoting the synthesis of antigenic proteins. This concurrent activation of the body’s principal immune mechanisms, namely...